Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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STK3 (serine/threonine kinase 3)

Identity

Other namesKRS1
MST2
HGNC (Hugo) STK3
LocusID (NCBI) 6788
Location 8q22.2
Location_base_pair Starts at 99466859 and ends at 99954799 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK3   11406
Cards
Entrez_Gene (NCBI)STK3  6788  serine/threonine kinase 3
GeneCards (Weizmann)STK3
Ensembl hg19 (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
ICGC DataPortalENSG00000104375
cBioPortalSTK3
AceView (NCBI)STK3
Genatlas (Paris)STK3
WikiGenes6788
SOURCE (Princeton)STK3
Genomic and cartography
GoldenPath hg19 (UCSC)STK3  -     chr8:99466859-99954799 -  8q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STK3  -     8q22.2   [Description]    (hg38-Dec_2013)
EnsemblSTK3 - 8q22.2 [CytoView hg19]  STK3 - 8q22.2 [CytoView hg38]
Mapping of homologs : NCBISTK3 [Mapview hg19]  STK3 [Mapview hg38]
OMIM605030   
Gene and transcription
Genbank (Entrez)AA370619 AK075229 AK131363 AK291837 AK307787
RefSeq transcript (Entrez)NM_001256312 NM_001256313 NM_006281
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)STK3
Cluster EST : UnigeneHs.492333 [ NCBI ]
CGAP (NCI)Hs.492333
Alternative Splicing : Fast-db (Paris)GSHG0029739
Alternative Splicing GalleryENSG00000104375
Gene ExpressionSTK3 [ NCBI-GEO ]     STK3 [ SEEK ]   STK3 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13188 (Uniprot)
NextProtQ13188  [Medical]
With graphics : InterProQ13188
Splice isoforms : SwissVarQ13188 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SARAH (PS50951)   
Domains : Interpro (EBI)Kinase-like_dom    Mst1_SARAH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    SARAH_dom    Ser/Thr_dual-sp_kinase   
Related proteins : CluSTrQ13188
Domain families : Pfam (Sanger)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam11629    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations6788
Blocks (Seattle)Q13188
PDB (SRS)4HKD    4L0N    4LG4    4LGD    4OH9   
PDB (PDBSum)4HKD    4L0N    4LG4    4LGD    4OH9   
PDB (IMB)4HKD    4L0N    4LG4    4LGD    4OH9   
PDB (RSDB)4HKD    4L0N    4LG4    4LGD    4OH9   
Human Protein AtlasENSG00000104375
Peptide AtlasQ13188
HPRD05433
IPIIPI00942120   IPI00411984   IPI00974494   IPI00978085   IPI00168325   
Protein Interaction databases
DIP (DOE-UCLA)Q13188
IntAct (EBI)Q13188
FunCoupENSG00000104375
BioGRIDSTK3
IntegromeDBSTK3
STRING (EMBL)STK3
Ontologies - Pathways
QuickGOQ13188
Ontology : AmiGOmagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell proliferation  signal transduction by phosphorylation  positive regulation of protein binding  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  protein stabilization  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBImagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell proliferation  signal transduction by phosphorylation  positive regulation of protein binding  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  protein stabilization  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGMAPK signaling pathway    Hippo signaling pathway   
Protein Interaction DatabaseSTK3
DoCM (Curated mutations)STK3
Wikipedia pathwaysSTK3
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSTK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK3
dbVarSTK3
ClinVarSTK3
1000_GenomesSTK3 
Exome Variant ServerSTK3
SNP (GeneSNP Utah)STK3
SNP : HGBaseSTK3
Genetic variants : HAPMAPSTK3
Genomic Variants (DGV)STK3 [DGVbeta]
Mutations
ICGC Data PortalENSG00000104375 
Somatic Mutations in Cancer : COSMICSTK3 
CONAN: Copy Number AnalysisSTK3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:99466859-99954799
Mutations and Diseases : HGMDSTK3
OMIM605030   
MedgenSTK3
NextProtQ13188 [Medical]
GENETestsSTK3
Disease Genetic AssociationSTK3
Huge Navigator STK3 [HugePedia]  STK3 [HugeCancerGEM]
snp3D : Map Gene to Disease6788
DGIdb (Drug Gene Interaction db)STK3
General knowledge
Homologs : HomoloGeneSTK3
Homology/Alignments : Family Browser (UCSC)STK3
Phylogenetic Trees/Animal Genes : TreeFamSTK3
Chemical/Protein Interactions : CTD6788
Chemical/Pharm GKB GenePA36213
Clinical trialSTK3
Cancer Resource (Charite)ENSG00000104375
Other databases
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
CoreMineSTK3
GoPubMedSTK3
iHOPSTK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:32:10 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.