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STK3 (serine/threonine kinase 3)

Identity

Other namesKRS1
MST2
HGNC (Hugo) STK3
LocusID (NCBI) 6788
Location 8q22.2
Location_base_pair Starts at 99466859 and ends at 99954799 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK3   11406
Cards
Entrez_Gene (NCBI)STK3  6788  serine/threonine kinase 3
GeneCards (Weizmann)STK3
Ensembl (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
ICGC DataPortalENSG00000104375
cBioPortalSTK3
AceView (NCBI)STK3
Genatlas (Paris)STK3
WikiGenes6788
SOURCE (Princeton)NM_001256312 NM_001256313 NM_006281
Genomic and cartography
GoldenPath (UCSC)STK3  -  8q22.2   chr8:99466859-99954799 -  8q22.2   [Description]    (hg19-Feb_2009)
EnsemblSTK3 - 8q22.2 [CytoView]
Mapping of homologs : NCBISTK3 [Mapview]
OMIM605030   
Gene and transcription
Genbank (Entrez)AA370619 AK075229 AK131363 AK291837 AK307787
RefSeq transcript (Entrez)NM_001256312 NM_001256313 NM_006281
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NT_008046 NW_001839136 NW_004929340
Consensus coding sequences : CCDS (NCBI)STK3
Cluster EST : UnigeneHs.492333 [ NCBI ]
CGAP (NCI)Hs.492333
Alternative Splicing : Fast-db (Paris)GSHG0029739
Alternative Splicing GalleryENSG00000104375
Gene ExpressionSTK3 [ NCBI-GEO ]     STK3 [ SEEK ]   STK3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13188 (Uniprot)
NextProtQ13188  [Medical]
With graphics : InterProQ13188
Splice isoforms : SwissVarQ13188 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SARAH (PS50951)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Mst1_SARAH_domain [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   SARAH_dom [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]  
Related proteins : CluSTrQ13188
Domain families : Pfam (Sanger)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam11629    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations6788
Blocks (Seattle)Q13188
PDB (SRS)4HKD    4L0N    4LG4    4LGD   
PDB (PDBSum)4HKD    4L0N    4LG4    4LGD   
PDB (IMB)4HKD    4L0N    4LG4    4LGD   
PDB (RSDB)4HKD    4L0N    4LG4    4LGD   
Human Protein AtlasENSG00000104375 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ13188
HPRD05433
IPIIPI00942120   IPI00411984   IPI00974494   IPI00978085   IPI00168325   
Protein Interaction databases
DIP (DOE-UCLA)Q13188
IntAct (EBI)Q13188
FunCoupENSG00000104375
BioGRIDSTK3
InParanoidQ13188
Interologous Interaction database Q13188
IntegromeDBSTK3
STRING (EMBL)STK3
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  signal transduction by phosphorylation  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  protein dimerization activity  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  
Ontology : EGO-EBImagnesium ion binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  signal transduction by phosphorylation  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  protein dimerization activity  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  
Pathways : KEGGMAPK signaling pathway    Hippo signaling pathway   
Protein Interaction DatabaseSTK3
Wikipedia pathwaysSTK3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STK3
snp3D : Map Gene to Disease6788
SNP (GeneSNP Utah)STK3
SNP : HGBaseSTK3
Genetic variants : HAPMAPSTK3
Exome VariantSTK3
1000_GenomesSTK3 
ICGC programENSG00000104375 
Somatic Mutations in Cancer : COSMICSTK3 
CONAN: Copy Number AnalysisSTK3 
Mutations and Diseases : HGMDSTK3
Mutations and Diseases : intOGenSTK3
Genomic VariantsSTK3  STK3 [DGVbeta]
dbVarSTK3
ClinVarSTK3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM605030   
MedgenSTK3
GENETestsSTK3
Disease Genetic AssociationSTK3
Huge Navigator STK3 [HugePedia]  STK3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSTK3
Homology/Alignments : Family Browser (UCSC)STK3
Phylogenetic Trees/Animal Genes : TreeFamSTK3
Chemical/Protein Interactions : CTD6788
Chemical/Pharm GKB GenePA36213
Clinical trialSTK3
Cancer Resource (Charite)ENSG00000104375
Other databases
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
CoreMineSTK3
iHOPSTK3
OncoSearchSTK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:20:55 CEST 2014

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