Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STK3 (serine/threonine kinase 3)

Identity

Other namesKRS1
MST2
HGNC (Hugo) STK3
LocusID (NCBI) 6788
Location 8q22.2
Location_base_pair Starts at 99466859 and ends at 99954799 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK3   11406
Entrez_Gene (NCBI)STK3  6788  serine/threonine kinase 3
Cards
GeneCards (Weizmann)STK3
Ensembl (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
AceView (NCBI)STK3
Genatlas (Paris)STK3
SOURCE (Stanford)NM_001256312 NM_001256313 NM_006281
Genomic and cartography
GoldenPath (UCSC)STK3  -  8q22.2   chr8:99466859-99954799 -  8q22.2   [Description]    (hg19-Feb_2009)
EnsemblSTK3 - 8q22.2 [CytoView]
Mapping of homologs : NCBISTK3 [Mapview]
OMIM605030   
Gene and transcription
Genbank (Entrez)AA370619 AK075229 AK131363 AK291837 AK307787
RefSeq transcript (SRS)NM_001256312 NM_001256313 NM_006281
RefSeq transcript (Entrez)NM_001256312 NM_001256313 NM_006281
RefSeq genomic (SRS)AC_000140 NC_000008 NC_018919 NT_008046 NW_001839136 NW_004078037
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NT_008046 NW_001839136 NW_004078037
Consensus coding sequences : CCDS (NCBI)STK3
Cluster EST : UnigeneHs.492333 [ SRS ] Hs.492333 [ NCBI ]
CGAP (NCI)Hs.492333
Alternative Splicing : Fast-db (Paris)GSHG0029739
Alternative Splicing GalleryENSG00000104375
Gene ExpressionSTK3 [ NCBI-GEO ]   STK3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13188 (SRS) Q13188 (Uniprot)
NextProtQ13188
With graphics : InterProQ13188
Splice isoforms : SwissVarQ13188(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SARAH (PS50951)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SARAH (PS50951)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SARAH    SARAH_domain    Ser/Thr_dual-sp_kinase_dom   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    SARAH    SARAH_domain    Ser/Thr_dual-sp_kinase_dom   
Related proteins : CluSTrQ13188
Domain families : Pfam (SRS)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (Sanger)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam11629    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM6788
Blocks (Seattle)Q13188
Human Protein AtlasENSG00000104375
HPRD05433
IPIIPI00942120   IPI00411984   IPI00974494   IPI00978085   IPI00168325   
Protein Interaction databases
DIP (DOE-UCLA)Q13188
IntAct (EBI)Q13188
FunCoupENSG00000104375
REACTOMESTK3
Protein Interaction Database6788
BioGRIDSTK3
InParanoidQ13188
Interologous Interaction database Q13188
IntegromeDBSTK3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STK3
SNP (GeneSNP Utah)STK3
SNP : HGBaseSTK3
Genetic variants : HAPMAPSTK3
Somatic Mutations in Cancer : COSMICSTK3 
CONAN: Copy Number AnalysisSTK3 
Mutations and Diseases : HGMDSTK3
OMIM605030   
GENETests605030   
Disease Genetic AssociationSTK3
Huge Navigator STK3 [HugePedia]  STK3 [HugeCancerGEM]
Genomic VariantsSTK3  STK3 [DGVbeta]
snp3D : Map Gene to Disease6788
General knowledge
Homologs : HomoloGeneSTK3
Homology/Alignments : Family Browser (UCSC)STK3
Phylogenetic Trees/Animal Genes : TreeFamSTK3
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD6788
Chemical/Pharm GKB GenePA36213
Clinical trialSTK3
Cancer Resource (Charite)ENSG00000104375
Ontology : AmiGOmagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  intracellular protein kinase cascade  central nervous system development  negative regulation of cell proliferation  hippo signaling cascade  hippo signaling cascade  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  positive regulation of protein kinase B signaling cascade  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt receptor signaling pathway  
Ontology : EGO-EBImagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  intracellular protein kinase cascade  central nervous system development  negative regulation of cell proliferation  hippo signaling cascade  hippo signaling cascade  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  positive regulation of protein kinase B signaling cascade  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt receptor signaling pathway  
Pathways : KEGGMAPK signaling pathway
Other databases
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
PubGeneSTK3
iHOPSTK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:38:29 CEST 2013
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