STK38 (serine/threonine kinase 38)

2006-10-01  

Identity

HGNC
LOCATION
6p21.31
LOCUSID
ALIAS
NDR,NDR1
FUSION GENES

Other Information

Locus ID:

NCBI: 11329
MIM: 606964
HGNC: 17847
Ensembl: ENSG00000112079

Variants:

dbSNP: 11329
ClinVar: 11329
TCGA: ENSG00000112079
COSMIC: STK38

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112079ENST00000229812Q15208
ENSG00000112079ENST00000229812A0A024RD18

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190622802008NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.73
151971862004Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.57
193279962009MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.52
161358142005Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation.51
212627722011Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.50
173176332007Centrosome-associated NDR kinase regulates centrosome duplication.47
150670042004Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.38
217302912011MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.29
206249132010Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.26
183628902008Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.24

Citation

Dessen P

STK38 (serine/threonine kinase 38)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43516/stk38