STK38L (serine/threonine kinase 38 like)

2006-10-01  

Identity

HGNC
STK38L
LOCATION
12p11.23
LOCUSID
23012
ALIAS
NDR2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23012
MIM: 615836
HGNC: 17848
Ensembl: ENSG00000211455

Variants:

dbSNP: 23012
ClinVar: 23012
TCGA: ENSG00000211455
COSMIC: STK38L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000211455ENST00000389032Q9Y2H1
ENSG00000211455ENST00000407753I3L0D0
ENSG00000211455ENST00000536093H0YGN4
ENSG00000211455ENST00000540996F5H7Z3
ENSG00000211455ENST00000541191F5GY51
ENSG00000211455ENST00000543246F5GY51
ENSG00000211455ENST00000544367F5H0V1
ENSG00000211455ENST00000544969F5GY51
ENSG00000211455ENST00000545470F5H277
ENSG00000211455ENST00000546286F5H5E6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
190622802008NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.73
163145232005Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.72
212627722011Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.50
234355662013NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.43
150670042004Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.38
155826652005HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.16
238978092013Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.15
307754392019NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages.9
164888892006NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling.8

Citation

Dessen P

STK38L (serine/threonine kinase 38 like)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43517/stk38l