Identity
HGNC
LOCATION
2q24.3
LOCUSID
ALIAS
DCHT,PASK,SPAK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 27347
MIM: 607648
HGNC: 17717
Ensembl: ENSG00000198648
Variants:
dbSNP: 27347
ClinVar: 27347
TCGA: ENSG00000198648
COSMIC: STK39
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000198648 | ENST00000355999 | Q9UEW8 |
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA134875400 | WNK4 | Gene | Pathway | associated | 23788015 | ||
| PA134973207 | OXSR1 | Gene | Pathway | associated | 23788015 | ||
| PA321 | SLC12A3 | Gene | Pathway | associated | 23788015 | ||
| PA33782 | WNK1 | Gene | Pathway | associated | 23788015 | ||
| PA33784 | WNK3 | Gene | Pathway | associated | 23788015 | ||
| PA450268 | losartan | Chemical | ClinicalAnnotation | associated | PD | 21993215 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36538242 | 2023 | CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway. | 2 |
| 36538242 | 2023 | CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway. | 2 |
| 34726826 | 2022 | Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains. | 1 |
| 34726826 | 2022 | Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains. | 1 |
| 34281492 | 2021 | Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1 /Smad2/3 pathway. | 9 |
| 34335956 | 2021 | STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. | 6 |
| 34374638 | 2021 | Knockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis. | 14 |
| 34519635 | 2021 | Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38. | 2 |
| 34678896 | 2021 | Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study. | 1 |
| 34281492 | 2021 | Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1 /Smad2/3 pathway. | 9 |
| 34335956 | 2021 | STK39 promotes breast cancer invasion and metastasis by increasing SNAI1 activity upon phosphorylation. | 6 |
| 34374638 | 2021 | Knockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis. | 14 |
| 34519635 | 2021 | Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38. | 2 |
| 34678896 | 2021 | Variant rs6749447 (T > G) in the serine threonine kinase gene is associated with cardiovascular complications, the Tampere adult population cardiovascular risk study. | 1 |
| 31614064 | 2020 | The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner. | 9 |
Citation
Dessen P
STK39 (serine/threonine kinase 39)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43518/stk39
