STN1 (STN1 subunit of CST complex)

2019-04-01 Affiliation

Identity

HGNC

STN1

LOCATION

10q24.33

LOCUSID

79991

ALIAS

AAF-44,AAF44,OBFC1,RPA-32,bA541N10.2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79991
MIM: 613128
HGNC: 26200
Ensembl: ENSG00000107960

Variants:

dbSNP: 79991
ClinVar: 79991
TCGA: ENSG00000107960
COSMIC: STN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000107960	ENST00000224950	Q9H668
ENSG00000107960	ENST00000369764	Q9H668

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	31327267
PA448499	atenolol	Chemical	ClinicalAnnotation	associated		PD	31327267

References

Pubmed ID	Year	Title	Citations
19854130	2009	RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.	162
22763445	2012	The human CST complex is a terminator of telomerase activity.	130
20421499	2010	Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.	122
20421499	2010	Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.	122
22863775	2012	Human CST promotes telomere duplex replication and general replication restart after fork stalling.	90
19119139	2009	A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells.	81
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
23142664	2012	Human CST has independent functions during telomere duplex replication and C-strand fill-in.	63
17903301	2007	Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study.	50
22964711	2012	Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.	47

Citation

Dessen P

STN1 (STN1 subunit of CST complex)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57880/stn1