STS (steroid sulfatase)

2007-02-01  

Identity

HGNC
LOCATION
Xp22.31
LOCUSID
ALIAS
ARSC,ARSC1,ASC,ES,SSDD,XLI
FUSION GENES

Other Information

Locus ID:

NCBI: 412
MIM: 300747
HGNC: 11425
Ensembl: ENSG00000101846

Variants:

dbSNP: 412
ClinVar: 412
TCGA: ENSG00000101846
COSMIC: STS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101846ENST00000217961P08842
ENSG00000101846ENST00000660000A0A590UJY9
ENSG00000101846ENST00000664306A0A590UJT4
ENSG00000101846ENST00000666110A0A590UJL0

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activationREACTOMER-HSA-163841
The activation of arylsulfatasesREACTOMER-HSA-1663150
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
262137852015The Regulation of Steroid Action by Sulfation and Desulfation.68
231225782013Placental steroidogenesis in pregnant women with polycystic ovary syndrome.44
184133702008X-linked ichthyosis (steroid sulfatase deficiency) is associated with increased risk of attention deficit hyperactivity disorder, autism and social communication deficits.39
126576382003Structure of human estrone sulfatase suggests functional roles of membrane association.36
150097112004Basis for abnormal desquamation and permeability barrier dysfunction in RXLI.28
189373002008Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder.27
189373002008Association of the steroid sulfatase (STS) gene with attention deficit hyperactivity disorder.27
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
153559162004Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.20

Citation

Dessen P

STS (steroid sulfatase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43814/sts