Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STUB1 (STIP1 homology and U-box containing protein 1)

Identity

Alias_symbol (synonym)UBOX1
CHIP
SDCCAG7
HSPABP2
NY-CO-7
Other aliasSCA48
SCAR16
HGNC (Hugo) STUB1
LocusID (NCBI) 10273
Atlas_Id 46980
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 680111 and ends at 682768 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
STUB1 (16p13.3) / STUB1 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STUB1   11427
Cards
Entrez_Gene (NCBI)STUB1  10273  STIP1 homology and U-box containing protein 1
AliasesCHIP; HSPABP2; NY-CO-7; SCA48; 
SCAR16; SDCCAG7; UBOX1
GeneCards (Weizmann)STUB1
Ensembl hg19 (Hinxton)ENSG00000103266 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103266 [Gene_View]  ENSG00000103266 [Sequence]  chr16:680111-682768 [Contig_View]  STUB1 [Vega]
ICGC DataPortalENSG00000103266
TCGA cBioPortalSTUB1
AceView (NCBI)STUB1
Genatlas (Paris)STUB1
WikiGenes10273
SOURCE (Princeton)STUB1
Genetics Home Reference (NIH)STUB1
Genomic and cartography
GoldenPath hg38 (UCSC)STUB1  -     chr16:680111-682768 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STUB1  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathSTUB1 - 16p13.3 [CytoView hg19]  STUB1 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000103266
Mapping of homologs : NCBISTUB1 [Mapview hg19]  STUB1 [Mapview hg38]
OMIM607207   615768   618093   
Gene and transcription
Genbank (Entrez)AF039689 AF129085 AF217968 AF432221 BC007545
RefSeq transcript (Entrez)NM_001293197 NM_005861
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STUB1
Cluster EST : UnigeneHs.592081 [ NCBI ]
CGAP (NCI)Hs.592081
Alternative Splicing GalleryENSG00000103266
Gene ExpressionSTUB1 [ NCBI-GEO ]   STUB1 [ EBI - ARRAY_EXPRESS ]   STUB1 [ SEEK ]   STUB1 [ MEM ]
Gene Expression Viewer (FireBrowse)STUB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10273
GTEX Portal (Tissue expression)STUB1
Human Protein AtlasENSG00000103266-STUB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNE7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNE7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNE7
Splice isoforms : SwissVarQ9UNE7
PhosPhoSitePlusQ9UNE7
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)    U_BOX (PS51698)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat    Ubox_domain    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)U-box (PF04564)   
Domain families : Pfam (NCBI)pfam04564   
Domain families : Smart (EMBL)TPR (SM00028)  Ubox (SM00504)  
Conserved Domain (NCBI)STUB1
DMDM Disease mutations10273
Blocks (Seattle)STUB1
PDB (RSDB)4KBQ   
PDB Europe4KBQ   
PDB (PDBSum)4KBQ   
PDB (IMB)4KBQ   
Structural Biology KnowledgeBase4KBQ   
SCOP (Structural Classification of Proteins)4KBQ   
CATH (Classification of proteins structures)4KBQ   
SuperfamilyQ9UNE7
Human Protein Atlas [tissue]ENSG00000103266-STUB1 [tissue]
Peptide AtlasQ9UNE7
HPRD06232
IPIIPI00025156   IPI00645380   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNE7
IntAct (EBI)Q9UNE7
FunCoupENSG00000103266
BioGRIDSTUB1
STRING (EMBL)STUB1
ZODIACSTUB1
Ontologies - Pathways
QuickGOQ9UNE7
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  G protein-coupled receptor binding  response to ischemia  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein quality control for misfolded or incompletely synthesized proteins  protein ubiquitination  protein ubiquitination  enzyme binding  kinase binding  Z disc  ubiquitin-dependent ERAD pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  Hsp70 protein binding  Hsp70 protein binding  ubiquitin-dependent SMAD protein catabolic process  protein binding, bridging  TPR domain binding  endoplasmic reticulum unfolded protein response  heat shock protein binding  ubiquitin conjugating enzyme complex  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  regulation of protein stability  regulation of glucocorticoid metabolic process  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-ubiquitin ligase activity  cellular response to heat  ERBB2 signaling pathway  nuclear inclusion body  protein homodimerization activity  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  SMAD binding  SMAD binding  tau protein binding  chaperone binding  positive regulation of ubiquitin-protein transferase activity  protein maturation  misfolded protein binding  protein autoubiquitination  Hsp90 protein binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  chaperone-mediated autophagy  protein K63-linked ubiquitination  cellular response to misfolded protein  cellular response to hypoxia  positive regulation of chaperone-mediated protein complex assembly  chaperone complex  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  G protein-coupled receptor binding  response to ischemia  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  protein quality control for misfolded or incompletely synthesized proteins  protein ubiquitination  protein ubiquitination  enzyme binding  kinase binding  Z disc  ubiquitin-dependent ERAD pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  Hsp70 protein binding  Hsp70 protein binding  ubiquitin-dependent SMAD protein catabolic process  protein binding, bridging  TPR domain binding  endoplasmic reticulum unfolded protein response  heat shock protein binding  ubiquitin conjugating enzyme complex  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  regulation of protein stability  regulation of glucocorticoid metabolic process  negative regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-ubiquitin ligase activity  cellular response to heat  ERBB2 signaling pathway  nuclear inclusion body  protein homodimerization activity  protein homodimerization activity  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  proteasome-mediated ubiquitin-dependent protein catabolic process  SMAD binding  SMAD binding  tau protein binding  chaperone binding  positive regulation of ubiquitin-protein transferase activity  protein maturation  misfolded protein binding  protein autoubiquitination  Hsp90 protein binding  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  ubiquitin protein ligase activity  chaperone-mediated autophagy  protein K63-linked ubiquitination  cellular response to misfolded protein  cellular response to hypoxia  positive regulation of chaperone-mediated protein complex assembly  chaperone complex  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum   
NDEx NetworkSTUB1
Atlas of Cancer Signalling NetworkSTUB1
Wikipedia pathwaysSTUB1
Orthology - Evolution
OrthoDB10273
GeneTree (enSembl)ENSG00000103266
Phylogenetic Trees/Animal Genes : TreeFamSTUB1
HOGENOMQ9UNE7
Homologs : HomoloGeneSTUB1
Homology/Alignments : Family Browser (UCSC)STUB1
Gene fusions - Rearrangements
Fusion : QuiverSTUB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTUB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STUB1
dbVarSTUB1
ClinVarSTUB1
1000_GenomesSTUB1 
Exome Variant ServerSTUB1
ExAC (Exome Aggregation Consortium)ENSG00000103266
GNOMAD BrowserENSG00000103266
Varsome BrowserSTUB1
Genetic variants : HAPMAP10273
Genomic Variants (DGV)STUB1 [DGVbeta]
DECIPHERSTUB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTUB1 
Mutations
ICGC Data PortalSTUB1 
TCGA Data PortalSTUB1 
Broad Tumor PortalSTUB1
OASIS PortalSTUB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTUB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTUB1
Mutations and Diseases : HGMDSTUB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STUB1
DgiDB (Drug Gene Interaction Database)STUB1
DoCM (Curated mutations)STUB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STUB1 (select a term)
intoGenSTUB1
Cancer3DSTUB1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607207    615768    618093   
Orphanet23040   
DisGeNETSTUB1
MedgenSTUB1
Genetic Testing Registry STUB1
NextProtQ9UNE7 [Medical]
TSGene10273
GENETestsSTUB1
Target ValidationSTUB1
Huge Navigator STUB1 [HugePedia]
snp3D : Map Gene to Disease10273
BioCentury BCIQSTUB1
ClinGenSTUB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10273
Chemical/Pharm GKB GenePA36227
Clinical trialSTUB1
Miscellaneous
canSAR (ICR)STUB1 (select the gene name)
DataMed IndexSTUB1
Probes
Litterature
PubMed417 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTUB1
EVEXSTUB1
GoPubMedSTUB1
iHOPSTUB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:10:13 CET 2019
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