STUB1 (STIP1 homology and U-box containing protein 1)

2007-04-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
CHIP,HSPABP2,NY-CO-7,SCA48,SCAR16,SDCCAG7,UBOX1
FUSION GENES

Other Information

Locus ID:

NCBI: 10273
MIM: 607207
HGNC: 11427
Ensembl: ENSG00000103266

Variants:

dbSNP: 10273
ClinVar: 10273
TCGA: ENSG00000103266
COSMIC: STUB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103266ENST00000219548Q9UNE7
ENSG00000103266ENST00000564316H3BTA3
ENSG00000103266ENST00000564370Q9UNE7
ENSG00000103266ENST00000565677Q9UNE7
ENSG00000103266ENST00000565813V9GYH3
ENSG00000103266ENST00000566408H3BUD0
ENSG00000103266ENST00000567173H3BS86

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by ERBB2REACTOMER-HSA-1227986
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173043502007The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.223
149629782004CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.219
163079172005Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.175
146124562004CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.133
159116282005The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.94
239732232013The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.92
199401512010Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.91
191969612009CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.78
125741672003ErbB2 degradation mediated by the co-chaperone protein CHIP.76
228248012013C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.76

Citation

Dessen P

STUB1 (STIP1 homology and U-box containing protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46980/stub1