STX17 (syntaxin 17)

2009-05-01  

Identity

HGNC
STX17
LOCATION
9q31.1
LOCUSID
55014
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55014
MIM: 604204
HGNC: 11432
Ensembl: ENSG00000136874

Variants:

dbSNP: 55014
ClinVar: 55014
TCGA: ENSG00000136874
COSMIC: STX17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136874ENST00000259400P56962
ENSG00000136874ENST00000524405E9PIC2
ENSG00000136874ENST00000525342E9PJV6
ENSG00000136874ENST00000525640P56962
ENSG00000136874ENST00000526607E9PJW1
ENSG00000136874ENST00000529340E9PQU9
ENSG00000136874ENST00000531035E9PJW1
ENSG00000136874ENST00000534052P56962

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
Autophagy - animalKEGGko04140
SNARE interactions in vesicular transportKEGGhsa04130
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381828882024The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.3
383403172024Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.2
387204722024SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.1
390083282024Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation.0
381828882024The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.3
383403172024Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion.2
387204722024SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma.1
390083282024Exacerbation of atherosclerosis by STX17 knockdown: Unravelling the role of autophagy and inflammation.0
373898642023ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.7
373898642023ULK phosphorylation of STX17 controls autophagosome maturation via FLNA.7
322647362021Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.46
331915432021A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.7
322647362021Acetylation of STX17 (syntaxin 17) controls autophagosome maturation.46
331915432021A SNARE protein Syntaxin 17 captures CFTR to potentiate autophagosomal clearance under stress.7
312511112020DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.21

Citation

Dessen P

STX17 (syntaxin 17)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50884/stx17