Identity
HGNC
LOCATION
12q24.33
LOCUSID
ALIAS
EPIM,EPM,STX2A,STX2B,STX2C
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2054
MIM: 132350
HGNC: 3403
Ensembl: ENSG00000111450
Variants:
dbSNP: 2054
ClinVar: 2054
TCGA: ENSG00000111450
COSMIC: STX2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000111450 | ENST00000261653 | P32856 |
| ENSG00000111450 | ENST00000344271 | J3KNU7 |
| ENSG00000111450 | ENST00000392373 | P32856 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36316316 | 2022 | Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis. | 2 |
| 36316316 | 2022 | Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis. | 2 |
| 33075373 | 2020 | STX2 drives colorectal cancer proliferation via upregulation of EXOSC4. | 4 |
| 33075373 | 2020 | STX2 drives colorectal cancer proliferation via upregulation of EXOSC4. | 4 |
| 29570232 | 2018 | STX2 is a causative gene for nonobstructive azoospermia. | 8 |
| 29767240 | 2018 | Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2. | 1 |
| 29855462 | 2018 | STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway. | 14 |
| 29570232 | 2018 | STX2 is a causative gene for nonobstructive azoospermia. | 8 |
| 29767240 | 2018 | Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2. | 1 |
| 29855462 | 2018 | STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway. | 14 |
| 28209294 | 2017 | Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-β-induced cell behaviors of human scar dermal fibroblasts. | 2 |
| 28209294 | 2017 | Sulfated glycosaminoglycans and non-classically secreted proteins, basic FGF and epimorphin, coordinately regulate TGF-β-induced cell behaviors of human scar dermal fibroblasts. | 2 |
| 27362846 | 2016 | HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells. | 5 |
| 27362846 | 2016 | HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells. | 5 |
| 24578379 | 2014 | Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. | 24 |
Citation
Dessen P
STX2 (syntaxin 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45908/stx2
