STX4 (syntaxin 4)

2016-10-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
STX4A,p35-2
FUSION GENES

Other Information

Locus ID:

NCBI: 6810
MIM: 186591
HGNC: 11439
Ensembl: ENSG00000103496

Variants:

dbSNP: 6810
ClinVar: 6810
TCGA: ENSG00000103496
COSMIC: STX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103496ENST00000313843Q12846
ENSG00000103496ENST00000394998Q12846
ENSG00000103496ENST00000457779C9JFM5
ENSG00000103496ENST00000460668H3BMK2
ENSG00000103496ENST00000496977H3BMK2
ENSG00000103496ENST00000613541A0A087WWW0

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Disinhibition of SNARE formationREACTOMER-HSA-114516
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA450921phenprocoumonChemicalClinicalAnnotationassociatedPD21063236
PA451906warfarinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
204349892010Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines.117
209565412010Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.25
213932402011Stimulus-induced S-nitrosylation of Syntaxin 4 impacts insulin granule exocytosis.20
128556812003Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell.17
205953822010Reduced plasma membrane expression of dysferlin mutants is attributed to accelerated endocytosis via a syntaxin-4-associated pathway.17
245522162014Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus.16
248079032014SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.16
298962022018Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition.14
153517102004Involvement of syntaxin 4 in the transport of membrane-type 1 matrix metalloproteinase to the plasma membrane in human gastric epithelial cells.11
257622042015Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.10

Citation

Dessen P

STX4 (syntaxin 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56250/stx4