STYK1 (serine/threonine/tyrosine kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
NOK,SuRTK106
FUSION GENES

Other Information

Locus ID:

NCBI: 55359
MIM: 611433
HGNC: 18889
Ensembl: ENSG00000060140

Variants:

dbSNP: 55359
ClinVar: 55359
TCGA: ENSG00000060140
COSMIC: STYK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060140ENST00000075503Q6J9G0
ENSG00000060140ENST00000535345F5GZF6
ENSG00000060140ENST00000538867F5H366
ENSG00000060140ENST00000541561F5H4G3
ENSG00000060140ENST00000542562F5H2I9
ENSG00000060140ENST00000542924H0YGL5

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359700442022Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.1
359700442022Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice.1
325728822020STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1.1
328712102020NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.2
325728822020STYK1 promotes the malignant progression of laryngeal squamous cell carcinoma through targeting TGF-β1.1
328712102020NOK associates with c-Src and promotes c-Src-induced STAT3 activation and cell proliferation.2
307015752019SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.10
311646312019STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.18
315422332019STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.42
307015752019SMAD3 inducing the transcription of  STYK1 to promote the EMT process and improve the tolerance of ovarian carcinoma cells to paclitaxel.10
311646312019STYK1 promotes tumor growth and metastasis by reducing SPINT2/HAI-2 expression in non-small cell lung cancer.18
315422332019STYK1/NOK correlates with ferroptosis in non-small cell lung carcinoma.42
294139472018STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.13
294139472018STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma.13
279839282017Knockdown of Serine Threonine Tyrosine Kinase 1 (STYK1) Inhibits the Migration and Tumorigenesis in Glioma Cells.2

Citation

Dessen P

STYK1 (serine/threonine/tyrosine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43519/styk1