SUGCT (succinyl-CoA:glutarate-CoA transferase)

2014-11-01  

Identity

HGNC
LOCATION
7p14.1
LOCUSID
ALIAS
C7orf10,DERP13,GA3,ORF19
FUSION GENES

Other Information

Locus ID:

NCBI: 79783
MIM: 609187
HGNC: 16001
Ensembl: ENSG00000175600

Variants:

dbSNP: 79783
ClinVar: 79783
TCGA: ENSG00000175600
COSMIC: SUGCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175600ENST00000335693Q9HAC7
ENSG00000175600ENST00000401647Q9HAC7
ENSG00000175600ENST00000413931H7C0H3
ENSG00000175600ENST00000416370H0Y4N1
ENSG00000175600ENST00000444074H7C1N0
ENSG00000175600ENST00000628514Q9HAC7

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA452637hormonal contraceptives for systemic useChemicalClinicalAnnotationassociatedPD28750087

References

Pubmed IDYearTitleCitations
222779672012Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.141
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
238930492014C7orf10 encodes succinate-hydroxymethylglutarate CoA-transferase, the enzyme that converts glutarate to glutaryl-CoA.14
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
189265132008Genetic mapping of glutaric aciduria, type 3, to chromosome 7 and identification of mutations in c7orf10.10
294216012018Novel contiguous gene deletion in peruvian girl with Trichothiodystrophy type 4 and glutaric aciduria type 3.3

Citation

Dessen P

SUGCT (succinyl-CoA:glutarate-CoA transferase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74358/sugct