SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)

2010-10-01  

Identity

HGNC
SUGT1
LOCATION
13q14.3
LOCUSID
10910
ALIAS
SGT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10910
MIM: 604098
HGNC: 16987
Ensembl: ENSG00000165416

Variants:

dbSNP: 10910
ClinVar: 10910
TCGA: ENSG00000165416
COSMIC: SUGT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165416ENST00000310528Q9Y2Z0
ENSG00000165416ENST00000343788Q9Y2Z0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
InflammasomesREACTOMER-HSA-622312
The NLRP3 inflammasomeREACTOMER-HSA-844456

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174204702007SGT1 is essential for Nod1 activation.55
239354902013The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.31
204041102010Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.30
174662732007Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.16
193985582009Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.16
127464582003Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins.12
228695222012Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.11
183582342008Sgt1 has co-chaperone properties and is up-regulated by heat shock.10
234405152013SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.10
231849432013Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.6

Citation

Dessen P

SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51737/sugt1