SULT1E1 (sulfotransferase family 1E member 1)

2003-08-01  

Identity

HGNC
SULT1E1
LOCATION
4q13.3
LOCUSID
6783
ALIAS
EST,EST-1,ST1E1,STE

Other Information

Locus ID:

NCBI: 6783
MIM: 600043
HGNC: 11377
Ensembl: ENSG00000109193

Variants:

dbSNP: 6783
ClinVar: 6783
TCGA: ENSG00000109193
COSMIC: SULT1E1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109193ENST00000226444P49888
ENSG00000109193ENST00000226444Q53X91

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448015acetaminophenChemicalLiterature, MultilinkAnnotation, Pathwayassociated23462933, 26049587

References

Pubmed IDYearTitleCitations
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
187941262008Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase.57
169852502006Estrogen sulfation genes, hormone replacement therapy, and endometrial cancer risk.28
118843922002Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction.26
223808442012Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.22
197762912010Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes.21
204295822010The human estrogen sulfotransferase: a half-site reactive enzyme.21
153559162004Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma.20
164180642005Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1.19

Citation

Dessen P

SULT1E1 (sulfotransferase family 1E member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42450/sult1e1