SUMO3 (small ubiquitin like modifier 3)

2010-06-01  

Identity

HGNC
SUMO3
LOCATION
21q22.3
LOCUSID
6612
ALIAS
SMT3A,SMT3H1,SUMO-3,Smt3B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6612
MIM: 602231
HGNC: 11124
Ensembl: ENSG00000184900

Variants:

dbSNP: 6612
ClinVar: 6612
TCGA: ENSG00000184900
COSMIC: SUMO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184900ENST00000332859P55854
ENSG00000184900ENST00000397893A8MU27
ENSG00000184900ENST00000397898A8MUA9
ENSG00000184900ENST00000411651P55854

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is proteolytically processedREACTOMER-HSA-3065679
SUMO is conjugated to E1 (UBA2:SAE1)REACTOMER-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
SUMOylation of transcription factorsREACTOMER-HSA-3232118
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183746472008SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.101
154569022004Distinct in vivo dynamics of vertebrate SUMO paralogues.91
187083562008Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.70
160557102005Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.69
185658752008The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle.65
237514932013RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.61
190292522009The CTCF insulator protein is posttranslationally modified by SUMO.56
125115582003A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3.50
189460852009RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.42
170122282006Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways.37

Citation

Dessen P

SUMO3 (small ubiquitin like modifier 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51514/sumo3