SUMO4 (small ubiquitin like modifier 4)

2014-11-01 Affiliation

Identity

HGNC

SUMO4

LOCATION

6q25.1

LOCUSID

387082

ALIAS

IDDM5,SMT3H4,SUMO-4,dJ281H8.4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 387082
MIM: 608829
HGNC: 21181
Ensembl: ENSG00000177688

Variants:

dbSNP: 387082
ClinVar: 387082
TCGA: ENSG00000177688
COSMIC: SUMO4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177688	ENST00000326669	Q6EEV6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
Nuclear pore complex	KEGG	hsa_M00427
Nuclear pore complex	KEGG	M00427
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447247	liver transplantation	Disease	ClinicalAnnotation	associated	PK		28941036
PA451578	tacrolimus	Chemical	ClinicalAnnotation	associated	PK		28941036

References

Pubmed ID	Year	Title	Citations
20448286	2010	Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.	16
17452059	2007	Genetics of type 1 diabetes in Asian and Caucasian populations.	14
18330586	2008	Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.	9
18330586	2008	Association study of NFKB1 and SUMO4 polymorphisms in Chinese patients with psoriasis vulgaris.	9
17130532	2006	Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.	7
18466472	2007	Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.	7
18466531	2007	Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.	7
16249223	2006	Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus.	4
16821265	2006	SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: a case-control study in a Spanish population.	4
17554341	2007	SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients.	4

Citation

Dessen P

SUMO4 (small ubiquitin like modifier 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74375/sumo4