SUPT20H (SPT20 homolog, SAGA complex component)

2007-02-01  

Identity

HGNC
SUPT20H
LOCATION
13q13.3
LOCUSID
55578
ALIAS
C13,C13orf19,FAM48A,FP757,P38IP,SPT20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55578
MIM: 613417
HGNC: 20596
Ensembl: ENSG00000102710

Variants:

dbSNP: 55578
ClinVar: 55578
TCGA: ENSG00000102710
COSMIC: SUPT20H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102710ENST00000350612Q8NEM7
ENSG00000102710ENST00000356185Q8NEM7
ENSG00000102710ENST00000356185A0A024RDW2
ENSG00000102710ENST00000360252Q8NEM7
ENSG00000102710ENST00000360252A0A024RDW2
ENSG00000102710ENST00000464744Q8NEM7
ENSG00000102710ENST00000464744A0A024RDW2
ENSG00000102710ENST00000469488H7C5F9
ENSG00000102710ENST00000475892Q8NEM7
ENSG00000102710ENST00000490716R4GND2
ENSG00000102710ENST00000495071B4E2D5
ENSG00000102710ENST00000497318C9JQS2
ENSG00000102710ENST00000542180F6S7C4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198934882010Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.100
191145502009The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes.31
275318772016p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma.8
242200282013The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5.7
120700152002Novel transcription factors in human CD34 antigen-positive hematopoietic cells.6
159783282005Quantification of C13orf19/P38IP mRNA expression by quantitative real-time PCR in patients with urological malignancies.3
113406312001Identification of a novel gene on chromosome 13 between BRCA-2 and RB-1.1
166854012006Functional analyses of C13orf19/P38IP in prostate cell lines.1
312103712019FAM48A mediates compensatory autophagy induced by proteasome impairment.0

Citation

Dessen P

SUPT20H (SPT20 homolog, SAGA complex component)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46059/supt20h