SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

2003-05-01 Affiliation

Identity

HGNC

SUPT4H1

LOCATION

17q22

LOCUSID

6827

ALIAS

SPT4,SPT4H,SUPT4H,Supt4a

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6827
MIM: 603555
HGNC: 11467
Ensembl: ENSG00000213246

Variants:

dbSNP: 6827
ClinVar: 6827
TCGA: ENSG00000213246
COSMIC: SUPT4H1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000213246	ENST00000225504	P63272
ENSG00000213246	ENST00000577396	D3DTZ5
ENSG00000213246	ENST00000579289	J3KSQ6
ENSG00000213246	ENST00000580947	P63272
ENSG00000213246	ENST00000581540	J3QSB9

Expression (GTEx)

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Elongation	REACTOME	R-HSA-167169
Formation of the HIV-1 Early Elongation Complex	REACTOME	R-HSA-167158
Tat-mediated elongation of the HIV-1 transcript	REACTOME	R-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 Tat	REACTOME	R-HSA-167200
Abortive elongation of HIV-1 transcript in the absence of Tat	REACTOME	R-HSA-167242
HIV elongation arrest and recovery	REACTOME	R-HSA-167287
Formation of HIV elongation complex in the absence of HIV Tat	REACTOME	R-HSA-167152
Pausing and recovery of HIV elongation	REACTOME	R-HSA-167290
Tat-mediated HIV elongation arrest and recovery	REACTOME	R-HSA-167243
Pausing and recovery of Tat-mediated HIV elongation	REACTOME	R-HSA-167238
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Elongation	REACTOME	R-HSA-75955
Formation of the Early Elongation Complex	REACTOME	R-HSA-113418
Formation of RNA Pol II elongation complex	REACTOME	R-HSA-112382
TP53 Regulates Transcription of DNA Repair Genes	REACTOME	R-HSA-6796648

References

Pubmed ID	Year	Title	Citations
33333262	2021	CRISPRi-mediated depletion of Spt4 and Spt5 reveals a role for DSIF in the control of HIV latency.	4
33333262	2021	CRISPRi-mediated depletion of Spt4 and Spt5 reveals a role for DSIF in the control of HIV latency.	4
30605685	2019	SUPT4H1 Depletion Leads to a Global Reduction in RNA.	9
30605685	2019	SUPT4H1 Depletion Leads to a Global Reduction in RNA.	9
27461012	2016	Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases.	22
27516603	2016	Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.	81
27461012	2016	Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases.	22
27516603	2016	Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts.	81
19210550	2009	Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis.	14
19860741	2009	Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.	16
19952111	2009	DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.	69
19210550	2009	Role of human transcription elongation factor DSIF in the suppression of senescence and apoptosis.	14
19860741	2009	Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.	16
19952111	2009	DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation.	69
17962196	2008	Interplay between E-box and NF-kappaB in regulation of A20 gene by DRB sensitivity-inducing factor (DSIF).	17

Citation

Dessen P

SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42452/supt4h1

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