SUPV3L1 (Suv3 like RNA helicase)

2007-04-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
SUV3
FUSION GENES

Other Information

Locus ID:

NCBI: 6832
MIM: 605122
HGNC: 11471
Ensembl: ENSG00000156502

Variants:

dbSNP: 6832
ClinVar: 6832
TCGA: ENSG00000156502
COSMIC: SUPV3L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156502ENST00000359655Q8IYB8
ENSG00000156502ENST00000422378B1AR60

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
198642552010Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance.55
232216312013Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct foci.53
195092882009Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality.43
124665302002Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA.39
186788732008Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells.34
150960472004Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change.19
173526922007Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
179616332007Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.16

Citation

Dessen P

SUPV3L1 (Suv3 like RNA helicase)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47109/supv3l1