SURF4 (surfeit 4)

2018-12-01  

Identity

HGNC
LOCATION
9q34.2
LOCUSID
ALIAS
ERV29
FUSION GENES

Other Information

Locus ID:

NCBI: 6836
MIM: 185660
HGNC: 11476
Ensembl: ENSG00000148248

Variants:

dbSNP: 6836
ClinVar: 6836
TCGA: ENSG00000148248
COSMIC: SURF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148248ENST00000371989O15260
ENSG00000148248ENST00000371991Q5T8U5
ENSG00000148248ENST00000485435O15260
ENSG00000148248ENST00000545297O15260
ENSG00000148248ENST00000613129B7Z1G8
ENSG00000148248ENST00000618229B7Z1G8

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182875282008The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.27
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
302516252018The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9.9
296431172018SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization.7
300861312018Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.6
297776982018SURF4 has oncogenic potential in NIH3T3 cells.2
316454502020Surfeit 4 Contributes to the Replication of Hepatitis C Virus Using Double-Membrane Vesicles.0
316764362020Surf4 regulates expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) but is not required for PCSK9 secretion in cultured human hepatocytes.0

Citation

Dessen P

SURF4 (surfeit 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57783/surf4