SUSD2 (sushi domain containing 2)

2013-11-01  

Identity

HGNC
SUSD2
LOCATION
22q11.23
LOCUSID
56241
ALIAS
BK65A6.2,W5C5

Other Information

Locus ID:

NCBI: 56241
MIM: 615825
HGNC: 30667
Ensembl: ENSG00000099994

Variants:

dbSNP: 56241
ClinVar: 56241
TCGA: ENSG00000099994
COSMIC: SUSD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099994ENST00000358321Q9UGT4
ENSG00000099994ENST00000358321A0A140VJW3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
231319942013Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.31
236245252013Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.18
268155032016SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer.12
284755992017SUSD2 promotes tumor-associated macrophage recruitment by increasing levels of MCP-1 in breast cancer.7
288416822017Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells.7
302597112018Expression of sushi domain containing two reflects the malignant potential of gastric cancer.4
303355442018Sushi Domain Containing 2 (SUSD2) inhibits platelet activation and binding to high-grade serous ovarian carcinoma cells.1
256771982015No evidence of association between polymorphisms in four genes and sporadic amyotrophic lateral sclerosis in Han Chinese.0

Citation

Dessen P

SUSD2 (sushi domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53553/susd2