SWAP70 (switching B cell complex subunit SWAP70)

2015-02-01  

Identity

HGNC
SWAP70
LOCATION
11p15.4
LOCUSID
23075
ALIAS
HSPC321,SWAP-70
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23075
MIM: 604762
HGNC: 17070
Ensembl: ENSG00000133789

Variants:

dbSNP: 23075
ClinVar: 23075
TCGA: ENSG00000133789
COSMIC: SWAP70

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133789ENST00000318950Q9UH65
ENSG00000133789ENST00000447399E7EMB1
ENSG00000133789ENST00000526358E9PJK8
ENSG00000133789ENST00000534562H0YDK5
ENSG00000133789ENST00000534662E9PJM7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213605652011SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer.22
164182212006Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling.21
222109192012Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation.19
129257602003SWAP-70 identifies a transitional subset of actin filaments in motile cells.15
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
278062922016SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis.12
258893422015The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity.5
173719382007Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation.3
222475622012Membrane-induced alteration of the secondary structure in the SWAP-70 pleckstrin homology domain.2
227289612012Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse.2

Citation

Dessen P

SWAP70 (switching B cell complex subunit SWAP70)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55041/swap70