SYCE1 (synaptonemal complex central element protein 1)

2014-11-01  

Identity

HGNC
SYCE1
LOCATION
10q26.3
LOCUSID
93426
ALIAS
C10orf94,CT76,POF12,SPGF15

Other Information

Locus ID:

NCBI: 93426
MIM: 611486
HGNC: 28852
Ensembl: ENSG00000171772

Variants:

dbSNP: 93426
ClinVar: 93426
TCGA: ENSG00000171772
COSMIC: SYCE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171772ENST00000303903A0A0B4J1R9
ENSG00000171772ENST00000343131Q8N0S2
ENSG00000171772ENST00000368517Q8N0S2
ENSG00000171772ENST00000432597A0A0A0MT28

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
250624522014Exome sequencing reveals SYCE1 mutation associated with autosomal recessive primary ovarian insufficiency.27
258999902015Deleterious mutation in SYCE1 is associated with non-obstructive azoospermia.20
306075102019Molecular structure of human synaptonemal complex protein SYCE1.5

Citation

Dessen P

SYCE1 (synaptonemal complex central element protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74397/syce1