SYMPK (symplekin)

2017-10-01  

Identity

HGNC
SYMPK
LOCATION
19q13.32
LOCUSID
8189
ALIAS
Pta1,SPK,SYM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8189
MIM: 602388
HGNC: 22935
Ensembl: ENSG00000125755

Variants:

dbSNP: 8189
ClinVar: 8189
TCGA: ENSG00000125755
COSMIC: SYMPK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125755ENST00000245934Q92797
ENSG00000125755ENST00000245934A0A024R0R6
ENSG00000125755ENST00000594293M0R1C2
ENSG00000125755ENST00000596824M0R033
ENSG00000125755ENST00000598059M0R180
ENSG00000125755ENST00000599460A0A087WUE9
ENSG00000125755ENST00000599814A0A087WUE9
ENSG00000125755ENST00000600237M0R3C7
ENSG00000125755ENST00000601600M0R039
ENSG00000125755ENST00000602061M0QXP5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNAs Derived from Intronless TranscriptsREACTOMER-HSA-159234
Transport of Mature mRNA Derived from an Intronless TranscriptREACTOMER-HSA-159231
Processing of Capped Intronless Pre-mRNAREACTOMER-HSA-75067
Processing of Intronless Pre-mRNAsREACTOMER-HSA-77595

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155502462004Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.143
208618392010Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.74
206016762010Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease.50
201338052010Symplekin promotes tumorigenicity by up-regulating claudin-2 expression.32
147071472004HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.25
193287952009The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.17
259210692015Global Promotion of Alternative Internal Exon Usage by mRNA 3' End Formation Factors.16
178805312007Alteration of adhesion molecule expression and cellular polarity in hepatocellular carcinoma.9
291672702018UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.9
208232742010Symplekin specifies mitotic fidelity by supporting microtubule dynamics.8

Citation

Dessen P

SYMPK (symplekin)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57217/sympk