SYN2 (synapsin II)

2014-11-01 Affiliation

Identity

HGNC

SYN2

LOCATION

3p25.2

LOCUSID

6854

ALIAS

SYNII

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6854
MIM: 600755
HGNC: 11495
Ensembl: ENSG00000157152

Variants:

dbSNP: 6854
ClinVar: 6854
TCGA: ENSG00000157152
COSMIC: SYN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157152	ENST00000425297	A0A087WW91
ENSG00000157152	ENST00000620175	Q92777
ENSG00000157152	ENST00000621198	Q92777

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Release Cycle	REACTOME	R-HSA-112310
Serotonin Neurotransmitter Release Cycle	REACTOME	R-HSA-181429
Dopamine Neurotransmitter Release Cycle	REACTOME	R-HSA-212676

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
17913586	2007	Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.	58
23956174	2014	SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth.	23
16131404	2005	Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.	18
17766091	2007	Association of synapsin 2 with schizophrenia in families of Northern European ancestry.	18
15449241	2004	Family-based association study of synapsin II and schizophrenia.	17
20034013	2010	Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.	17
20034013	2010	Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.	17
15271586	2004	Positive association between synapsin II and schizophrenia.	14

Citation

Dessen P

SYN2 (synapsin II)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74407/syn2