SYT7 (synaptotagmin 7)

2003-02-01  

Identity

HGNC
SYT7
LOCATION
11q12.2
LOCUSID
9066
ALIAS
IPCA-7,IPCA7,PCANAP7,SYT-VII,SYTVII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9066
MIM: 604146
HGNC: 11514
Ensembl: ENSG00000011347

Variants:

dbSNP: 9066
ClinVar: 9066
TCGA: ENSG00000011347
COSMIC: SYT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011347ENST00000263846O43581
ENSG00000011347ENST00000535826O43581
ENSG00000011347ENST00000539008O43581
ENSG00000011347ENST00000539246F5GX00
ENSG00000011347ENST00000539468F5GX00
ENSG00000011347ENST00000540677O43581
ENSG00000011347ENST00000542670O43581
ENSG00000011347ENST00000542836O43581
ENSG00000011347ENST00000545053F5H8G7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120718502002Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.24
279971242017Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail.17
229668492012Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7.16
290887002017Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses.16
276097732016Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis.13
272075202016Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.12
298586002018SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
254377582014Lateral diffusion of proteins on supported lipid bilayers: additive friction of synaptotagmin 7 C2A-C2B tandem domains.8

Citation

Dessen P

SYT7 (synaptotagmin 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41658/syt7