SYTL2 (synaptotagmin like 2)

2008-12-01  

Identity

HGNC
LOCATION
11q14.1
LOCUSID
ALIAS
CHR11SYT,EXO4,PPP1R151,SGA72M,SLP2,SLP2A
FUSION GENES

Other Information

Locus ID:

NCBI: 54843
MIM: 612880
HGNC: 15585
Ensembl: ENSG00000137501

Variants:

dbSNP: 54843
ClinVar: 54843
TCGA: ENSG00000137501
COSMIC: SYTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137501ENST00000316356Q9HCH5
ENSG00000137501ENST00000354566A0A0U1RQP0
ENSG00000137501ENST00000359152Q9HCH5
ENSG00000137501ENST00000389958Q9HCH5
ENSG00000137501ENST00000389959A0A0U1RRJ3
ENSG00000137501ENST00000389960Q9HCH5
ENSG00000137501ENST00000524452Q9HCH5
ENSG00000137501ENST00000524911E9PS39
ENSG00000137501ENST00000525702Q9HCH5
ENSG00000137501ENST00000526999E9PRW5
ENSG00000137501ENST00000527523Q9HCH5
ENSG00000137501ENST00000527794E9PPL3
ENSG00000137501ENST00000528231Q9HCH5
ENSG00000137501ENST00000529534E9PS29
ENSG00000137501ENST00000529581Q9HCH5
ENSG00000137501ENST00000530351A0A0U1RQH1
ENSG00000137501ENST00000532221E9PK22
ENSG00000137501ENST00000532995E9PIB5
ENSG00000137501ENST00000533057E9PQL8
ENSG00000137501ENST00000533577A0A1Y8EH08
ENSG00000137501ENST00000533892Q9HCH5
ENSG00000137501ENST00000634661A0A0U1RR07

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
117730822002The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.54
182667822008Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.29
188124752008A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion.21
188325762008Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.21
207291992010Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.18
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17
171828432007Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain.11
272202832016Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer.5
206541572010[Relationship between SLP-2 expression and prognosis in laryngeal squamous cell carcinoma and mammary invasive carcinoma].2
212236882010[Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion].0

Citation

Dessen P

SYTL2 (synaptotagmin like 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50549/sytl2