TAAR1 (trace amine associated receptor 1)

2018-07-01  

Identity

HGNC
TAAR1
LOCATION
6q23.2
LOCUSID
134864
ALIAS
TA1,TAR1,TRAR1

Other Information

Locus ID:

NCBI: 134864
MIM: 609333
HGNC: 17734
Ensembl: ENSG00000146399

Variants:

dbSNP: 134864
ClinVar: 134864
TCGA: ENSG00000146399
COSMIC: TAAR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146399ENST00000275216Q96RJ0

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
168781372006A second class of chemosensory receptors in the olfactory epithelium.219
198927332009The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.65
210734682011The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.57
216701042011Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.45
220793472012Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1.31
220381572012Trace amine associated receptor 1 signaling in activated lymphocytes.26
233154252013Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.25
221142632011Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA).20
270316172016Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.20
179007092007Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes.18

Citation

Dessen P

TAAR1 (trace amine associated receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57405/taar1