TAAR6 (trace amine associated receptor 6)

2014-11-01  

Identity

HGNC
LOCATION
6q23.2
LOCUSID
ALIAS
TA4,TAR4,TAR6,TRAR4,taR-4,taR-6

Other Information

Locus ID:

NCBI: 319100
MIM: 608923
HGNC: 20978
Ensembl: ENSG00000146383

Variants:

dbSNP: 319100
ClinVar: 319100
TCGA: ENSG00000146383
COSMIC: TAAR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146383ENST00000275198Q96RI8

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD19345712
PA10832corticosteroidsChemicalClinicalAnnotationassociatedPD25919112
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD25919112
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD19345712

References

Pubmed IDYearTitleCitations
168781372006A second class of chemosensory receptors in the olfactory epithelium.219
181982662008No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.111
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
195827692010Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.2
196435842009Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.2
196435842009Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.2
197661662009TAAR 6 and HSP-70 variations associated with bipolar disorder.2
197661662009TAAR 6 and HSP-70 variations associated with bipolar disorder.2
153297992004Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.0
160751872006Failure to find association between TRAR4 and schizophrenia in the Chinese Han population.0

Citation

Dessen P

TAAR6 (trace amine associated receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74452/taar6