TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)

2010-02-01 Affiliation

Identity

HGNC

TAB3

LOCATION

Xp21.2

LOCUSID

257397

ALIAS

MAP3K7IP3,NAP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 257397
MIM: 300480
HGNC: 30681
Ensembl: ENSG00000157625

Variants:

dbSNP: 257397
ClinVar: 257397
TCGA: ENSG00000157625
COSMIC: TAB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000157625	ENST00000288422	A0A0A0MQY2
ENSG00000157625	ENST00000378930	Q8N5C8
ENSG00000157625	ENST00000378932	Q8N5C8
ENSG00000157625	ENST00000378933	Q8N5C8
ENSG00000157625	ENST00000467136	F6SS63

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
IRAK2 mediated activation of TAK1 complex	REACTOME	R-HSA-937042
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	REACTOME	R-HSA-445989
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	REACTOME	R-HSA-450321
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
TRAF6 mediated induction of TAK1 complex	REACTOME	R-HSA-937072
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	REACTOME	R-HSA-975163
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
NOD1/2 Signaling Pathway	REACTOME	R-HSA-168638
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated NF-kB activation	REACTOME	R-HSA-2871837
C-type lectin receptors (CLRs)	REACTOME	R-HSA-5621481
CLEC7A (Dectin-1) signaling	REACTOME	R-HSA-5607764
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Signal Transduction	REACTOME	R-HSA-162582
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
TNFR1-induced NFkappaB signaling pathway	REACTOME	R-HSA-5357956
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15327770	2004	TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.	285
22660635	2012	The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α.	144
22158122	2011	Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation.	62
24565101	2014	MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.	55
17158449	2007	TAK1-dependent signaling requires functional interaction with TAB2/TAB3.	53
22081109	2011	Inhibition of autophagy by TAB2 and TAB3.	40
24434549	2014	TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3.	37
26676784	2015	Human MicroRNA miR-532-5p Exhibits Antiviral Activity against West Nile Virus via Suppression of Host Genes SESTD1 and TAB3 Required for Virus Replication.	22
30760523	2019	G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells.	4
23286385	2013	Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma.	3

Citation

Dessen P

TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51346/tab3