Identity
HGNC
LOCATION
2p12
LOCUSID
ALIAS
NK1R,NKIR,SPR,TAC1R
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6869
MIM: 162323
HGNC: 11526
Ensembl: ENSG00000115353
Variants:
dbSNP: 6869
ClinVar: 6869
TCGA: ENSG00000115353
COSMIC: TACR1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115353 | ENST00000305249 | P25103 |
| ENSG00000115353 | ENST00000409848 | P25103 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10352 | palonosetron | Chemical | VariantAnnotation | not associated | PD | 29177570 | |
| PA445048 | Nausea | Disease | VariantAnnotation | not associated | PD | 29177570 | |
| PA446051 | Vomiting | Disease | VariantAnnotation | not associated | PD | 29177570 | |
| PA449809 | granisetron | Chemical | VariantAnnotation | not associated | PD | 29177570 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37013432 | 2024 | Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis. | 0 |
| 37013432 | 2024 | Alpha Calcitonin Gene-related Peptide, Neuropeptide Y, and Substance P as Biomarkers for Diagnosis and Disease Activity and Severity in Multiple Sclerosis. | 0 |
| 36629320 | 2023 | Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis. | 1 |
| 36651605 | 2023 | The neuropeptide substance P/neurokinin-1 receptor system and diabetes: From mechanism to therapy. | 1 |
| 37408182 | 2023 | Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjögren's Syndrome (pSS) Pathogenesis. | 0 |
| 37454559 | 2023 | TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. | 2 |
| 36629320 | 2023 | Neurokinin-1 receptor is highly expressed in cervical cancer and its antagonist induces cervical cancer cell apoptosis. | 1 |
| 36651605 | 2023 | The neuropeptide substance P/neurokinin-1 receptor system and diabetes: From mechanism to therapy. | 1 |
| 37408182 | 2023 | Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjögren's Syndrome (pSS) Pathogenesis. | 0 |
| 37454559 | 2023 | TNF-α evokes blood-brain barrier dysfunction through activation of Rho-kinase and neurokinin 1 receptor. | 2 |
| 34773642 | 2022 | Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines. | 4 |
| 35013118 | 2022 | Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR. | 16 |
| 35434136 | 2022 | The Neurokinin-1 Receptor Is Essential for the Viability of Human Glioma Cells: A Possible Target for Treating Glioblastoma. | 10 |
| 35600049 | 2022 | A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641. | 6 |
| 35726575 | 2022 | Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells. | 4 |
Citation
Dessen P
TACR1 (tachykinin receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-05-01
Online version: http://atlasgeneticsoncology.org/gene/47535/tacr1
