TACR1 (tachykinin receptor 1)

2007-05-01  

Identity

HGNC
LOCATION
2p12
LOCUSID
ALIAS
NK1R,NKIR,SPR,TAC1R
FUSION GENES

Other Information

Locus ID:

NCBI: 6869
MIM: 162323
HGNC: 11526
Ensembl: ENSG00000115353

Variants:

dbSNP: 6869
ClinVar: 6869
TCGA: ENSG00000115353
COSMIC: TACR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115353ENST00000305249P25103
ENSG00000115353ENST00000409848P25103

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Tachykinin receptors bind tachykininsREACTOMER-HSA-380095
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10352palonosetronChemicalVariantAnnotationnot associatedPD29177570
PA445048NauseaDiseaseVariantAnnotationnot associatedPD29177570
PA446051VomitingDiseaseVariantAnnotationnot associatedPD29177570
PA449809granisetronChemicalVariantAnnotationnot associatedPD29177570

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
210917162011Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.44
187138532008Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor.38
127527722003Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain.37
155906762005The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity.34
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
200081422010MicroRNAs may mediate the down-regulation of neurokinin-1 receptor in chronic bladder pain syndrome.33
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32
125943382003Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter.30
204680642010Association study of 182 candidate genes in anorexia nervosa.30

Citation

Dessen P

TACR1 (tachykinin receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-05-01

Online version: http://atlasgeneticsoncology.org/gene/47535/tacr1