TACR2 (tachykinin receptor 2)

2013-04-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
NK2R,NKNAR,SKR,TAC2R

Other Information

Locus ID:

NCBI: 6865
MIM: 162321
HGNC: 11527
Ensembl: ENSG00000075073

Variants:

dbSNP: 6865
ClinVar: 6865
TCGA: ENSG00000075073
COSMIC: TACR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075073ENST00000373306P21452
ENSG00000075073ENST00000373307A6NEW7
ENSG00000075073ENST00000619173A0A087WZ80

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Tachykinin receptors bind tachykininsREACTOMER-HSA-380095
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
205032872010Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.17
128018822003PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.14
152948962004Dynamic confinement of NK2 receptors in the plasma membrane. Improved FRAP analysis and biological relevance.12
182038132008Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.12
201758032009Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment.11
224740182012Neuropeptide signaling activates dendritic cell-mediated type 1 immune responses through neurokinin-2 receptor.8

Citation

Dessen P

TACR2 (tachykinin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53237/tacr2