TADA3 (transcriptional adaptor 3)

2009-10-01  

Identity

HGNC
LOCATION
3p25.3
LOCUSID
ALIAS
ADA3,NGG1,STAF54,TADA3L,hADA3
FUSION GENES

Other Information

Locus ID:

NCBI: 10474
MIM: 602945
HGNC: 19422
Ensembl: ENSG00000171148

Variants:

dbSNP: 10474
ClinVar: 10474
TCGA: ENSG00000171148
COSMIC: TADA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171148ENST00000301964O75528
ENSG00000171148ENST00000343450O75528
ENSG00000171148ENST00000343450A0A024R2D7
ENSG00000171148ENST00000439043C9JMS0
ENSG00000171148ENST00000440161O75528

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
121381912002Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3.46
122351592002Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator.30
172722772007An essential role of human Ada3 in p53 acetylation.18
174529802007hAda3 regulates p14ARF-induced p53 acetylation and senescence.17
280603822017Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.17
227367702012Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression.16
154964192004Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation.15
180898092007Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation.13
182561482008hAda3 degradation by papillomavirus type 16 E6 correlates with abrogation of the p14ARF-p53 pathway and efficient immortalization of human mammary epithelial cells.11

Citation

Dessen P

TADA3 (transcriptional adaptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51166/tada3