TAF1 (TATA-box binding protein associated factor 1)

2006-10-01  

Identity

HGNC
TAF1
LOCATION
Xq13.1
LOCUSID
6872
ALIAS
BA2R,CCG1,CCGS,DYT3,DYT3/TAF1,KAT4,MRXS33,N-TAF1,NSCL2,OF,P250,TAF(II)250,TAF2A,TAFII-250,TAFII250,XDP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6872
MIM: 313650
HGNC: 11535
Ensembl: ENSG00000147133

Variants:

dbSNP: 6872
ClinVar: 6872
TCGA: ENSG00000147133
COSMIC: TAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147133ENST00000276072P21675
ENSG00000147133ENST00000373775H7BY98
ENSG00000147133ENST00000373790P21675
ENSG00000147133ENST00000423759P21675
ENSG00000147133ENST00000437147H7C2K9
ENSG00000147133ENST00000463163H0Y8N6
ENSG00000147133ENST00000483985H0Y9L7

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Basal transcription factorsKEGGhsa03022
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
172739612007Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism.55
263657972015A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.47
150538792004Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression.43
266379822015TAF1 Variants Are Associated with Dysmorphic Features, Intellectual Disability, and Neurological Manifestations.25
158703002005TAF1 histone acetyltransferase activity in Sp1 activation of the cyclin D1 promoter.21
254126592014Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.19
242899242014Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response.18
124986902002The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF.16
249275292014Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.15
201817222010TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains.14

Citation

Dessen P

TAF1 (TATA-box binding protein associated factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43523/taf1