TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C)

2015-09-01  

Identity

HGNC
LOCATION
16q24.1
LOCUSID
ALIAS
MGC:39976,SL1,TAFI110,TAFI95

Other Information

Locus ID:

NCBI: 9013
MIM: 604905
HGNC: 11534
Ensembl: ENSG00000103168

Variants:

dbSNP: 9013
ClinVar: 9013
TCGA: ENSG00000103168
COSMIC: TAF1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103168ENST00000341690Q15572
ENSG00000103168ENST00000541676Q15572
ENSG00000103168ENST00000561955H3BQZ8
ENSG00000103168ENST00000563428H3BQH8
ENSG00000103168ENST00000564345H3BNH3
ENSG00000103168ENST00000564454H3BUZ7
ENSG00000103168ENST00000566732Q15572
ENSG00000103168ENST00000566903H3BR91
ENSG00000103168ENST00000567759Q15572
ENSG00000103168ENST00000568265H3BR71
ENSG00000103168ENST00000569505H3BTQ6
ENSG00000103168ENST00000569609H3BMQ4
ENSG00000103168ENST00000570117Q15572

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
SIRT1 negatively regulates rRNA ExpressionREACTOMER-HSA-427359
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924

References

Pubmed IDYearTitleCitations
206639232010A genome-wide scan for common alleles affecting risk for autism.239
160557042005PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex.45
159705932005TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.30
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
260237732015Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.11
255512962015Frameshift mutations of TAF1C gene, a core component for transcription by RNA polymerase I, and its regional heterogeneity in gastric and colorectal cancers.1
310394362019Association of TATA box-binding protein-associated factor RNA polymerase I subunit C (TAF1C) with T2DM.0

Citation

Dessen P

TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55405/taf1c