TAF6 (TATA-box binding protein associated factor 6)

2014-11-01 Affiliation

Identity

HGNC

TAF6

LOCATION

7q22.1

LOCUSID

6878

ALIAS

ALYUS,MGC:8964,TAF(II)70,TAF(II)80,TAF2E,TAFII-70,TAFII-80,TAFII70,TAFII80,TAFII85

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6878
MIM: 602955
HGNC: 11540
Ensembl: ENSG00000106290

Variants:

dbSNP: 6878
ClinVar: 6878
TCGA: ENSG00000106290
COSMIC: TAF6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106290	ENST00000344095	P49848
ENSG00000106290	ENST00000417349	C9JHQ8
ENSG00000106290	ENST00000421980	F8WEJ7
ENSG00000106290	ENST00000431404	C9JI39
ENSG00000106290	ENST00000437822	P49848
ENSG00000106290	ENST00000440225	C9JFL8
ENSG00000106290	ENST00000449571	C9JIS2
ENSG00000106290	ENST00000451699	C9J7C4
ENSG00000106290	ENST00000452041	P49848
ENSG00000106290	ENST00000452438	C9J088
ENSG00000106290	ENST00000453269	P49848
ENSG00000106290	ENST00000460673	A0A1D5RMS5
ENSG00000106290	ENST00000472509	J3KR72
ENSG00000106290	ENST00000493322	C9JTY6
ENSG00000106290	ENST00000520135	E5RKA5
ENSG00000106290	ENST00000523306	E5RHA1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Basal transcription factors	KEGG	ko03022
Basal transcription factors	KEGG	hsa03022
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Transcription of the HIV genome	REACTOME	R-HSA-167172
HIV Transcription Initiation	REACTOME	R-HSA-167161
RNA Polymerase II HIV Promoter Escape	REACTOME	R-HSA-167162
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Pre-transcription Events	REACTOME	R-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	REACTOME	R-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter Clearance	REACTOME	R-HSA-76042
RNA Polymerase II Transcription Initiation	REACTOME	R-HSA-75953
RNA Polymerase II Promoter Escape	REACTOME	R-HSA-73776
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Phosphorylation	REACTOME	R-HSA-6804756
RNA polymerase II transcribes snRNA genes	REACTOME	R-HSA-6807505

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15601843	2005	Core promoter binding by histone-like TAF complexes.	33
22696218	2012	TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.	13
18628956	2008	TAF6delta controls apoptosis and gene expression in the absence of p53.	8
15328371	2004	TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.	7
20096117	2010	TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.	6
29358700	2018	BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.	2
25025302	2014	Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements.	1

Citation

Dessen P

TAF6 (TATA-box binding protein associated factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74472/taf6