TANK (TRAF family member associated NFKB activator)

2003-06-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
I-TRAF,ITRAF,TRAF2
FUSION GENES

Other Information

Locus ID:

NCBI: 10010
MIM: 603893
HGNC: 11562
Ensembl: ENSG00000136560

Variants:

dbSNP: 10010
ClinVar: 10010
TCGA: ENSG00000136560
COSMIC: TANK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136560ENST00000259075Q92844
ENSG00000136560ENST00000392749Q92844
ENSG00000136560ENST00000402568E7EW82
ENSG00000136560ENST00000403609Q92844
ENSG00000136560ENST00000405852E7EQA9
ENSG00000136560ENST00000406287E7EVA2
ENSG00000136560ENST00000429217E7ENY2
ENSG00000136560ENST00000432002E7EV32
ENSG00000136560ENST00000432692E7EM55
ENSG00000136560ENST00000437623H7C3L4
ENSG00000136560ENST00000439442H7BZ28
ENSG00000136560ENST00000440506E7EWR8
ENSG00000136560ENST00000441987E9PEK1
ENSG00000136560ENST00000456358E7EMT6
ENSG00000136560ENST00000457887E7ERM9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonREACTOMER-HSA-936964
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
TRAF6 mediated IRF7 activationREACTOMER-HSA-933541

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
173272202007Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.83
175687782007SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.67
121338332002Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.50
178231242007Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.37
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
216255352011Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action.28
145172192003Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling.25
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
258619892015TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.19

Citation

Dessen P

TANK (TRAF family member associated NFKB activator)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42468/tank