TAPBP (TAP binding protein)

2003-02-01  

Identity

HGNC
TAPBP
LOCATION
6p21.32
LOCUSID
6892
ALIAS
NGS17,TAPA,TPN,TPSN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6892
MIM: 601962
HGNC: 11566
Ensembl: ENSG00000231925

Variants:

dbSNP: 6892
ClinVar: 6892
TCGA: ENSG00000231925
COSMIC: TAPBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000231925ENST00000426633A0A0A0MSV9
ENSG00000231925ENST00000434618O15533
ENSG00000231925ENST00000434618A0A024RCT1
ENSG00000231925ENST00000456592Q6P1N7
ENSG00000231925ENST00000467025C9JA35
ENSG00000231925ENST00000475304A2AB90
ENSG00000231925ENST00000489157A0A0A0MT98

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Antigen processing and presentationKEGGhsa04612
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
Antigen processing-Cross presentationREACTOMER-HSA-1236975
ER-Phagosome pathwayREACTOMER-HSA-1236974

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD23736108
PA448497aspirinChemicalClinicalAnnotationassociatedPD23736108

References

Pubmed IDYearTitleCitations
119708752002Optimization of the MHC class I peptide cargo is dependent on tapasin.98
191190252009Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer.91
163222892005Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors.54
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
161930702005Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex.50
146079302003Tapasin is a facilitator, not an editor, of class I MHC peptide binding.29
118235312002Recruitment of MHC class I molecules by tapasin into the transporter associated with antigen processing-associated complex is essential for optimal peptide loading.28
125948552003A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression.26
267544812016Molecular mechanism of peptide editing in the tapasin-MHC I complex.23
145196252003Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients.22

Citation

Dessen P

TAPBP (TAP binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42470/tapbp