TAPBPL (TAP binding protein like)

2011-07-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
TAPBP-R,TAPBPR
FUSION GENES

Other Information

Locus ID:

NCBI: 55080
MIM: 607081
HGNC: 30683
Ensembl: ENSG00000139192

Variants:

dbSNP: 55080
ClinVar: 55080
TCGA: ENSG00000139192
COSMIC: TAPBPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139192ENST00000266556Q9BX59
ENSG00000139192ENST00000544021G3V1T3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
234015592013Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway.29
290259912017Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation.29
290259962017Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing.27
264390102015TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst.26
268697172016Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.19
241634102013The binding of TAPBPR and Tapasin to MHC class I is mutually exclusive.17
299880682018Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.14
284259172017TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway.13
213623302011Association of defective HLA-I expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer.8

Citation

Dessen P

TAPBPL (TAP binding protein like)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52284/tapbpl