TARBP2 (TARBP2 subunit of RISC loading complex)

2007-02-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
LOQS,TRBP,TRBP1,TRBP2

Other Information

Locus ID:

NCBI: 6895
MIM: 605053
HGNC: 11569
Ensembl: ENSG00000139546

Variants:

dbSNP: 6895
ClinVar: 6895
TCGA: ENSG00000139546
COSMIC: TARBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139546ENST00000266987Q15633
ENSG00000139546ENST00000394357Q15633
ENSG00000139546ENST00000456234Q15633
ENSG00000139546ENST00000547064F8VSA1
ENSG00000139546ENST00000548971F8VTT7
ENSG00000139546ENST00000549572F8VYK3
ENSG00000139546ENST00000549679F8VYK6
ENSG00000139546ENST00000550147F8VP94
ENSG00000139546ENST00000550407F8VZ57
ENSG00000139546ENST00000551741F8VZZ7
ENSG00000139546ENST00000552817H3BV98
ENSG00000139546ENST00000552857F8VW32

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Gene Silencing by RNAREACTOMER-HSA-211000
MicroRNA (miRNA) biogenesisREACTOMER-HSA-203927
Small interfering RNA (siRNA) biogenesisREACTOMER-HSA-426486

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181786192008In vitro reconstitution of the human RISC-loading complex.169
174523272007Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.104
190471282008Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.99
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95
198207102009Structural insights into RNA processing by the human RISC-loading complex.93
236616842013Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.73
255575502015Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.66
194226932009Characterization of the TRBP domain required for dicer interaction and function in RNA interference.59
189361602009TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.55
207329062010Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.50

Citation

Dessen P

TARBP2 (TARBP2 subunit of RISC loading complex)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45570/tarbp2