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TARS1 (threonyl-tRNA synthetase 1)

Identity

Alias_namesTARS
threonyl-tRNA synthetase
Other aliasThrRS
HGNC (Hugo) TARS1
LocusID (NCBI) 6897
Atlas_Id 55224
Location 5p13.3  [Link to chromosome band 5p13]
Location_base_pair Starts at 33440776 and ends at 33468091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZFR 5p13.3 / TARS 5p13.3
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ZFR/TARS (5p13)


External links

Nomenclature
HGNC (Hugo)TARS1   11572
Cards
Entrez_Gene (NCBI)TARS1  6897  threonyl-tRNA synthetase 1
AliasesTARS; ThrRS
GeneCards (Weizmann)TARS1
Ensembl hg19 (Hinxton)ENSG00000113407 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113407 [Gene_View]  ENSG00000113407 [Sequence]  chr5:33440776-33468091 [Contig_View]  TARS1 [Vega]
ICGC DataPortalENSG00000113407
TCGA cBioPortalTARS1
AceView (NCBI)TARS1
Genatlas (Paris)TARS1
WikiGenes6897
SOURCE (Princeton)TARS1
Genetics Home Reference (NIH)TARS1
Genomic and cartography
GoldenPath hg38 (UCSC)TARS1  -     chr5:33440776-33468091 +  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TARS1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathTARS1 - - [CytoView hg19]  TARS1 - - [CytoView hg38]
ImmunoBaseENSG00000113407
Mapping of homologs : NCBITARS1 [Mapview hg19]  TARS1 [Mapview hg38]
OMIM187790   
Gene and transcription
Genbank (Entrez)AK095852 AK222804 AK292346 AK293620 AK296783
RefSeq transcript (Entrez)NM_001258437 NM_001258438 NM_152295
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TARS1
Cluster EST : UnigeneHs.481860 [ NCBI ]
CGAP (NCI)Hs.481860
Alternative Splicing GalleryENSG00000113407
Gene ExpressionTARS1 [ NCBI-GEO ]   TARS1 [ EBI - ARRAY_EXPRESS ]   TARS1 [ SEEK ]   TARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6897
GTEX Portal (Tissue expression)TARS1
Human Protein AtlasENSG00000113407-TARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26639   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26639  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26639
Splice isoforms : SwissVarP26639
Catalytic activity : Enzyme6.1.1.3 [ Enzyme-Expasy ]   6.1.1.36.1.1.3 [ IntEnz-EBI ]   6.1.1.3 [ BRENDA ]   6.1.1.3 [ KEGG ]   
PhosPhoSitePlusP26639
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synt_IIb    aa-tRNA-synth_II    Anticodon-bd    Anticodon-bd_dom_sf    Beta-grasp_dom_sf    TGS    TGS-like    Thr-tRNA-ligase_IIa    Thr/Ala-tRNA-synth_IIc_edit    ThrRS_core    tRNA_SAD   
Domain families : Pfam (Sanger)HGTP_anticodon (PF03129)    TGS (PF02824)    tRNA-synt_2b (PF00587)    tRNA_SAD (PF07973)   
Domain families : Pfam (NCBI)pfam03129    pfam02824    pfam00587    pfam07973   
Domain families : Smart (EMBL)tRNA_SAD (SM00863)  
Conserved Domain (NCBI)TARS1
DMDM Disease mutations6897
Blocks (Seattle)TARS1
PDB (RSDB)1WWT    4HWT    4P3N    4TTV   
PDB Europe1WWT    4HWT    4P3N    4TTV   
PDB (PDBSum)1WWT    4HWT    4P3N    4TTV   
PDB (IMB)1WWT    4HWT    4P3N    4TTV   
Structural Biology KnowledgeBase1WWT    4HWT    4P3N    4TTV   
SCOP (Structural Classification of Proteins)1WWT    4HWT    4P3N    4TTV   
CATH (Classification of proteins structures)1WWT    4HWT    4P3N    4TTV   
SuperfamilyP26639
Human Protein Atlas [tissue]ENSG00000113407-TARS1 [tissue]
Peptide AtlasP26639
HPRD01762
IPIIPI00329633   IPI01012172   IPI00910719   IPI00965896   IPI00908949   IPI00966149   IPI00965598   IPI00967989   IPI00966983   IPI00965253   IPI00966670   
Protein Interaction databases
DIP (DOE-UCLA)P26639
IntAct (EBI)P26639
FunCoupENSG00000113407
BioGRIDTARS1
STRING (EMBL)TARS1
ZODIACTARS1
Ontologies - Pathways
QuickGOP26639
Ontology : AmiGOtRNA binding  threonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  actin cytoskeleton  protein homodimerization activity  extracellular exosome  
Ontology : EGO-EBItRNA binding  threonine-tRNA ligase activity  threonine-tRNA ligase activity  threonine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  threonyl-tRNA aminoacylation  actin cytoskeleton  protein homodimerization activity  extracellular exosome  
NDEx NetworkTARS1
Atlas of Cancer Signalling NetworkTARS1
Wikipedia pathwaysTARS1
Orthology - Evolution
OrthoDB6897
GeneTree (enSembl)ENSG00000113407
Phylogenetic Trees/Animal Genes : TreeFamTARS1
HOGENOMP26639
Homologs : HomoloGeneTARS1
Homology/Alignments : Family Browser (UCSC)TARS1
Gene fusions - Rearrangements
Fusion : MitelmanZFR/TARS [5p13.3/5p13.3]  [t(5;5)(p13;p13)]  
Fusion PortalZFR 5p13.3 TARS 5p13.3 BRCA
Fusion : QuiverTARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TARS1
dbVarTARS1
ClinVarTARS1
1000_GenomesTARS1 
Exome Variant ServerTARS1
ExAC (Exome Aggregation Consortium)ENSG00000113407
GNOMAD BrowserENSG00000113407
Varsome BrowserTARS1
Genetic variants : HAPMAP6897
Genomic Variants (DGV)TARS1 [DGVbeta]
DECIPHERTARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTARS1 
Mutations
ICGC Data PortalTARS1 
TCGA Data PortalTARS1 
Broad Tumor PortalTARS1
OASIS PortalTARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TARS1
DgiDB (Drug Gene Interaction Database)TARS1
DoCM (Curated mutations)TARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TARS1 (select a term)
intoGenTARS1
Cancer3DTARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187790   
Orphanet
DisGeNETTARS1
MedgenTARS1
Genetic Testing Registry TARS1
NextProtP26639 [Medical]
TSGene6897
GENETestsTARS1
Target ValidationTARS1
Huge Navigator TARS1 [HugePedia]
snp3D : Map Gene to Disease6897
BioCentury BCIQTARS1
ClinGenTARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6897
Chemical/Pharm GKB GenePA36337
Clinical trialTARS1
Miscellaneous
canSAR (ICR)TARS1 (select the gene name)
DataMed IndexTARS1
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTARS1
EVEXTARS1
GoPubMedTARS1
iHOPTARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:10:49 CET 2019

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