TAS1R1 (taste 1 receptor member 1)

2018-02-01  

Identity

HGNC
LOCATION
1p36.31
LOCUSID
ALIAS
GM148,GPR70,T1R1,TR1
FUSION GENES

Other Information

Locus ID:

NCBI: 80835
MIM: 606225
HGNC: 14448
Ensembl: ENSG00000173662

Variants:

dbSNP: 80835
ClinVar: 80835
TCGA: ENSG00000173662
COSMIC: TAS1R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173662ENST00000333172Q7RTX1
ENSG00000173662ENST00000351136Q7RTX1
ENSG00000173662ENST00000411823H7C3W7
ENSG00000173662ENST00000415267H0Y6X0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118940992002An amino-acid taste receptor.306
177243302007Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.278
153535922004Different functional roles of T1R subunits in the heteromeric taste receptors.134
195870852009Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.34
204680642010Association study of 182 candidate genes in anorexia nervosa.30
206600572010Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.24
224277942012Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.21
195712232009Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate.18
242149762013Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).15
214223782011Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function.14

Citation

Dessen P

TAS1R1 (taste 1 receptor member 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57322/tas1r1