TAS1R2 (taste 1 receptor member 2)

2014-11-01 Affiliation

Identity

HGNC

TAS1R2

LOCATION

1p36.13

LOCUSID

80834

ALIAS

GPR71,T1R2,TR2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80834
MIM: 606226
HGNC: 14905
Ensembl: ENSG00000179002

Variants:

dbSNP: 80834
ClinVar: 80834
TCGA: ENSG00000179002
COSMIC: TAS1R2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179002	ENST00000375371	Q8TE23

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742
Carbohydrate digestion and absorption	KEGG	ko04973
Carbohydrate digestion and absorption	KEGG	hsa04973
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499

References

Pubmed ID	Year	Title	Citations
14636554	2003	The receptors for mammalian sweet and umami taste.	348
22315413	2012	Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.	68
21540445	2011	The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.	49
20858777	2010	Taste genes associated with dental caries.	37
20858777	2010	Taste genes associated with dental caries.	37
20943793	2010	Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.	35
20943793	2010	Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.	35
24068707	2013	Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.	31
17935609	2007	The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor.	30
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30

Citation

Dessen P

TAS1R2 (taste 1 receptor member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74485/tas1r2