TAS1R3 (taste 1 receptor member 3)

2014-11-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
T1R3

Other Information

Locus ID:

NCBI: 83756
MIM: 605865
HGNC: 15661
Ensembl: ENSG00000169962

Variants:

dbSNP: 83756
ClinVar: 83756
TCGA: ENSG00000169962
COSMIC: TAS1R3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169962ENST00000339381Q7RTX0

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118940992002An amino-acid taste receptor.306
153535922004Different functional roles of T1R subunits in the heteromeric taste receptors.134
156682512005Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.80
152990242004The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.76
213245682011The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).57
195596182009Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose.55
195596182009Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose.55
215404452011The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.49
195870852009Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.34
195870852009Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes.34

Citation

Dessen P

TAS1R3 (taste 1 receptor member 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74486/tas1r3