TAX1BP3 (Tax1 binding protein 3)

2004-08-01  

Identity

HGNC
TAX1BP3
LOCATION
17p13.2
LOCUSID
30851
ALIAS
TIP-1,TIP1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 30851
MIM: 616484
HGNC: 30684
Ensembl: ENSG00000213977

Variants:

dbSNP: 30851
ClinVar: 30851
TCGA: ENSG00000213977
COSMIC: TAX1BP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213977ENST00000225525O14907
ENSG00000213977ENST00000611779A0A087X282

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate Rhotekin and RhophilinsREACTOMER-HSA-5666185

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
128742782003The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells.35
168550242006TIP-1 has PDZ scaffold antagonist activity.23
211395822011The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.23
154928122004The PDZ protein Tip-1 is a gain of function target of the HPV16 E6 oncoprotein.18
196354852009Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.13
217877502011Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein.12
235631762014Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.11
225647362012The PDZ protein TIP-1 facilitates cell migration and pulmonary metastasis of human invasive breast cancer cells in athymic mice.9
186907052008Probing the structure and function of human glutaminase-interacting protein: a possible target for drug design.8
256455152015Mutations in TAX1BP3 cause dilated cardiomyopathy with septo-optic dysplasia.7

Citation

Dessen P

TAX1BP3 (Tax1 binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2004-08-01

Online version: http://atlasgeneticsoncology.org/gene/42918/tax1bp3