TBC1D15 (TBC1 domain family member 15)

2014-08-01  

Identity

HGNC
LOCATION
12q21.1
LOCUSID
ALIAS
RAB7-GAP
FUSION GENES

Other Information

Locus ID:

NCBI: 64786
MIM: 612662
HGNC: 25694
Ensembl: ENSG00000121749

Variants:

dbSNP: 64786
ClinVar: 64786
TCGA: ENSG00000121749
COSMIC: TBC1D15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121749ENST00000319106Q8TC07
ENSG00000121749ENST00000462788F8WCB5
ENSG00000121749ENST00000468049F8WDJ1
ENSG00000121749ENST00000472611F8WF35
ENSG00000121749ENST00000482439F8VV61
ENSG00000121749ENST00000485960Q8TC07
ENSG00000121749ENST00000491063C9JA93
ENSG00000121749ENST00000498482F8WAX5
ENSG00000121749ENST00000550746Q8TC07

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
TBC/RABGAPsREACTOMER-HSA-8854214
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
245694792014Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy.90
203637362010Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.43
230771782013Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology.40
160550872005TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7.39
243379442014Silencing of TBC1D15 promotes RhoA activation and membrane blebbing.4
303169252019TBC1D15 affects glucose uptake by regulating GLUT4 translocation.2

Citation

Dessen P

TBC1D15 (TBC1 domain family member 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54689/tbc1d15