Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TBCB (tubulin folding cofactor B)

Identity

Alias_namesCKAP1
cytoskeleton-associated protein 1
cytoskeleton associated protein 1
Alias_symbol (synonym)CG22
CKAPI
Other alias
HGNC (Hugo) TBCB
LocusID (NCBI) 1155
Atlas_Id 54692
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 36115770 and ends at 36125941 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBCB (19q13.12) / B3GALNT1 (3q26.1)TBCB (19q13.12) / EIF4EBP2 (10q22.1)TBCB (19q13.12) / LOC728554 (5q35.3)
TBCB (19q13.12) / SERPINB2 (18q21.33)UBE4B (1p36.22) / TBCB (19q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Small Cell Carcinoma
t(1;19)(p36;q13) UBE4B/TBCB

External links

Nomenclature
HGNC (Hugo)TBCB   1989
Cards
Entrez_Gene (NCBI)TBCB  1155  tubulin folding cofactor B
AliasesCG22; CKAP1; CKAPI
GeneCards (Weizmann)TBCB
Ensembl hg19 (Hinxton)ENSG00000105254 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105254 [Gene_View]  ENSG00000105254 [Sequence]  chr19:36115770-36125941 [Contig_View]  TBCB [Vega]
ICGC DataPortalENSG00000105254
TCGA cBioPortalTBCB
AceView (NCBI)TBCB
Genatlas (Paris)TBCB
WikiGenes1155
SOURCE (Princeton)TBCB
Genetics Home Reference (NIH)TBCB
Genomic and cartography
GoldenPath hg38 (UCSC)TBCB  -     chr19:36115770-36125941 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBCB  -     19q13.12   [Description]    (hg19-Feb_2009)
GoldenPathTBCB - 19q13.12 [CytoView hg19]  TBCB - 19q13.12 [CytoView hg38]
ImmunoBaseENSG00000105254
Mapping of homologs : NCBITBCB [Mapview hg19]  TBCB [Mapview hg38]
OMIM601303   
Gene and transcription
Genbank (Entrez)AF013488 AI126083 AI148860 AL555345 BC005969
RefSeq transcript (Entrez)NM_001281 NM_001300971
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBCB
Alternative Splicing GalleryENSG00000105254
Gene ExpressionTBCB [ NCBI-GEO ]   TBCB [ EBI - ARRAY_EXPRESS ]   TBCB [ SEEK ]   TBCB [ MEM ]
Gene Expression Viewer (FireBrowse)TBCB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1155
GTEX Portal (Tissue expression)TBCB
Human Protein AtlasENSG00000105254-TBCB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99426   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99426  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99426
Splice isoforms : SwissVarQ99426
PhosPhoSitePlusQ99426
Domaine pattern : Prosite (Expaxy)CAP_GLY_1 (PS00845)    CAP_GLY_2 (PS50245)   
Domains : Interpro (EBI)CAP-Gly_dom_sf    CAP-Gly_domain    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)CAP_GLY (PF01302)    Ubiquitin_2 (PF14560)   
Domain families : Pfam (NCBI)pfam01302    pfam14560   
Domain families : Smart (EMBL)CAP_GLY (SM01052)  
Conserved Domain (NCBI)TBCB
DMDM Disease mutations1155
Blocks (Seattle)TBCB
SuperfamilyQ99426
Human Protein Atlas [tissue]ENSG00000105254-TBCB [tissue]
Peptide AtlasQ99426
HPRD03196
IPIIPI00293126   IPI00798211   
Protein Interaction databases
DIP (DOE-UCLA)Q99426
IntAct (EBI)Q99426
FunCoupENSG00000105254
BioGRIDTBCB
STRING (EMBL)TBCB
ZODIACTBCB
Ontologies - Pathways
QuickGOQ99426
Ontology : AmiGOprotein binding  cytoplasm  cytosol  nervous system development  microtubule cytoskeleton  cell differentiation  
Ontology : EGO-EBIprotein binding  cytoplasm  cytosol  nervous system development  microtubule cytoskeleton  cell differentiation  
NDEx NetworkTBCB
Atlas of Cancer Signalling NetworkTBCB
Wikipedia pathwaysTBCB
Orthology - Evolution
OrthoDB1155
GeneTree (enSembl)ENSG00000105254
Phylogenetic Trees/Animal Genes : TreeFamTBCB
HOGENOMQ99426
Homologs : HomoloGeneTBCB
Homology/Alignments : Family Browser (UCSC)TBCB
Gene fusions - Rearrangements
Fusion : MitelmanUBE4B/TBCB [1p36.22/19q13.12]  [t(1;19)(p36;q13)]  
Fusion : QuiverTBCB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBCB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBCB
dbVarTBCB
ClinVarTBCB
1000_GenomesTBCB 
Exome Variant ServerTBCB
ExAC (Exome Aggregation Consortium)ENSG00000105254
GNOMAD BrowserENSG00000105254
Varsome BrowserTBCB
Genetic variants : HAPMAP1155
Genomic Variants (DGV)TBCB [DGVbeta]
DECIPHERTBCB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBCB 
Mutations
ICGC Data PortalTBCB 
TCGA Data PortalTBCB 
Broad Tumor PortalTBCB
OASIS PortalTBCB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBCB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBCB
Mutations and Diseases : HGMDTBCB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBCB
DgiDB (Drug Gene Interaction Database)TBCB
DoCM (Curated mutations)TBCB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBCB (select a term)
intoGenTBCB
Cancer3DTBCB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601303   
Orphanet
DisGeNETTBCB
MedgenTBCB
Genetic Testing Registry TBCB
NextProtQ99426 [Medical]
TSGene1155
GENETestsTBCB
Target ValidationTBCB
Huge Navigator TBCB [HugePedia]
snp3D : Map Gene to Disease1155
BioCentury BCIQTBCB
ClinGenTBCB
Clinical trials, drugs, therapy
Protein Interactions : CTD1155
Pharm GKB GenePA162405357
Clinical trialTBCB
Miscellaneous
canSAR (ICR)TBCB (select the gene name)
HarmonizomeTBCB
DataMed IndexTBCB
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBCB
EVEXTBCB
GoPubMedTBCB
iHOPTBCB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:33:21 CEST 2020
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