TBPL1 (TATA-box binding protein like 1)

2015-02-01  

Identity

HGNC
TBPL1
LOCATION
6q23.2
LOCUSID
9519
ALIAS
MGC:8389,MGC:9620,STUD,TLF,TLP,TRF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9519
MIM: 605521
HGNC: 11589
Ensembl: ENSG00000028839

Variants:

dbSNP: 9519
ClinVar: 9519
TCGA: ENSG00000028839
COSMIC: TBPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000028839ENST00000237264P62380
ENSG00000028839ENST00000367869Q7Z6U0
ENSG00000028839ENST00000367871Q7Z6U2
ENSG00000028839ENST00000416965Q7Z6U1
ENSG00000028839ENST00000457715Q7Z6T9
ENSG00000028839ENST00000613034P62380

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Huntington's diseaseKEGGko05016
Basal transcription factorsKEGGhsa03022
Huntington's diseaseKEGGhsa05016
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
157676692005TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP.17
248707912014MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells.17
198582042009TATA-binding Protein (TBP)-like Protein Is Engaged in Etoposide-induced Apoptosis through Transcriptional Activation of Human TAp63 Gene.10
225117632012TATA-binding protein (TBP)-like protein is required for p53-dependent transcriptional activation of upstream promoter of p21Waf1/Cip1 gene.10
152692812004Cell-specific nucleolar localization of TBP-related factor 2.8
245948052014Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter.4
263980092015Tumor suppressor microRNA-18a regulates tumor proliferation and invasion by targeting TBPL1 in colorectal cancer cells.4
280826822017TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.3
156733182005Iron overload in kidney transplants: prospective analysis of biochemical and genetic markers.2
193696472009Identification of potentially damaging amino acid substitutions leading to human male infertility.2

Citation

Dessen P

TBPL1 (TATA-box binding protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55048/tbpl1