Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TBX15 (T-box transcription factor 15)

Identity

Alias_namesTBX14
T-box 14
T-box 15
Other alias
HGNC (Hugo) TBX15
LocusID (NCBI) 6913
Atlas_Id 54693
Location 1p12  [Link to chromosome band 1p12]
Location_base_pair Starts at 118883047 and ends at 118989510 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX20 (1p13.2) / TBX15 (1p12)HPS1 (10q24.2) / TBX15 (1p12)IGSF3 (1p13.1) / TBX15 (1p12)
DDX20 1p13.2 / TBX15 1p12IGSF3 1p13.1 / TBX15 1p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p12;p13) DDX20/TBX15

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p12;p13) IGSF3/TBX15

External links

Nomenclature
HGNC (Hugo)TBX15   11594
Cards
Entrez_Gene (NCBI)TBX15  6913  T-box transcription factor 15
AliasesTBX14
GeneCards (Weizmann)TBX15
Ensembl hg19 (Hinxton)ENSG00000092607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092607 [Gene_View]  ENSG00000092607 [Sequence]  chr1:118883047-118989510 [Contig_View]  TBX15 [Vega]
ICGC DataPortalENSG00000092607
TCGA cBioPortalTBX15
AceView (NCBI)TBX15
Genatlas (Paris)TBX15
WikiGenes6913
SOURCE (Princeton)TBX15
Genetics Home Reference (NIH)TBX15
Genomic and cartography
GoldenPath hg38 (UCSC)TBX15  -     chr1:118883047-118989510 -  1p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBX15  -     1p12   [Description]    (hg19-Feb_2009)
GoldenPathTBX15 - 1p12 [CytoView hg19]  TBX15 - 1p12 [CytoView hg38]
ImmunoBaseENSG00000092607
Mapping of homologs : NCBITBX15 [Mapview hg19]  TBX15 [Mapview hg38]
OMIM260660   604127   
Gene and transcription
Genbank (Entrez)AK096396 AK127536 BC122553 BX537778 CA412451
RefSeq transcript (Entrez)NM_001330677 NM_152380
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBX15
Alternative Splicing GalleryENSG00000092607
Gene ExpressionTBX15 [ NCBI-GEO ]   TBX15 [ EBI - ARRAY_EXPRESS ]   TBX15 [ SEEK ]   TBX15 [ MEM ]
Gene Expression Viewer (FireBrowse)TBX15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6913
GTEX Portal (Tissue expression)TBX15
Human Protein AtlasENSG00000092607-TBX15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SF7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SF7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SF7
Splice isoforms : SwissVarQ96SF7
PhosPhoSitePlusQ96SF7
Domaine pattern : Prosite (Expaxy)TBOX_1 (PS01283)    TBOX_2 (PS01264)    TBOX_3 (PS50252)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    T-box_sf    TF_T-box    TF_T-box_CS   
Domain families : Pfam (Sanger)T-box (PF00907)   
Domain families : Pfam (NCBI)pfam00907   
Domain families : Smart (EMBL)TBOX (SM00425)  
Conserved Domain (NCBI)TBX15
DMDM Disease mutations6913
Blocks (Seattle)TBX15
SuperfamilyQ96SF7
Human Protein Atlas [tissue]ENSG00000092607-TBX15 [tissue]
Peptide AtlasQ96SF7
HPRD16035
IPIIPI00163361   IPI00643004   IPI00844280   IPI00874142   
Protein Interaction databases
DIP (DOE-UCLA)Q96SF7
IntAct (EBI)Q96SF7
FunCoupENSG00000092607
BioGRIDTBX15
STRING (EMBL)TBX15
ZODIACTBX15
Ontologies - Pathways
QuickGOQ96SF7
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  protein binding  nucleus  protein homodimerization activity  positive regulation of transcription by RNA polymerase II  embryonic cranial skeleton morphogenesis  RNA polymerase II transcription repressor complex  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  RNA polymerase II activating transcription factor binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  cell fate specification  protein binding  nucleus  protein homodimerization activity  positive regulation of transcription by RNA polymerase II  embryonic cranial skeleton morphogenesis  RNA polymerase II transcription repressor complex  
NDEx NetworkTBX15
Atlas of Cancer Signalling NetworkTBX15
Wikipedia pathwaysTBX15
Orthology - Evolution
OrthoDB6913
GeneTree (enSembl)ENSG00000092607
Phylogenetic Trees/Animal Genes : TreeFamTBX15
HOGENOMQ96SF7
Homologs : HomoloGeneTBX15
Homology/Alignments : Family Browser (UCSC)TBX15
Gene fusions - Rearrangements
Fusion : MitelmanDDX20/TBX15 [1p13.2/1p12]  [t(1;1)(p12;p13)]  
Fusion : MitelmanIGSF3/TBX15 [1p13.1/1p12]  [t(1;1)(p12;p13)]  
Fusion PortalDDX20 1p13.2 TBX15 1p12 LAML
Fusion PortalIGSF3 1p13.1 TBX15 1p12 BRCA
Fusion : QuiverTBX15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBX15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBX15
dbVarTBX15
ClinVarTBX15
1000_GenomesTBX15 
Exome Variant ServerTBX15
ExAC (Exome Aggregation Consortium)ENSG00000092607
GNOMAD BrowserENSG00000092607
Varsome BrowserTBX15
Genetic variants : HAPMAP6913
Genomic Variants (DGV)TBX15 [DGVbeta]
DECIPHERTBX15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBX15 
Mutations
ICGC Data PortalTBX15 
TCGA Data PortalTBX15 
Broad Tumor PortalTBX15
OASIS PortalTBX15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTBX15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTBX15
Mutations and Diseases : HGMDTBX15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TBX15
DgiDB (Drug Gene Interaction Database)TBX15
DoCM (Curated mutations)TBX15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBX15 (select a term)
intoGenTBX15
Cancer3DTBX15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260660    604127   
Orphanet12268   
DisGeNETTBX15
MedgenTBX15
Genetic Testing Registry TBX15
NextProtQ96SF7 [Medical]
TSGene6913
GENETestsTBX15
Target ValidationTBX15
Huge Navigator TBX15 [HugePedia]
snp3D : Map Gene to Disease6913
BioCentury BCIQTBX15
ClinGenTBX15
Clinical trials, drugs, therapy
Protein Interactions : CTD6913
Pharm GKB GenePA36357
Clinical trialTBX15
Miscellaneous
canSAR (ICR)TBX15 (select the gene name)
HarmonizomeTBX15
DataMed IndexTBX15
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBX15
EVEXTBX15
GoPubMedTBX15
iHOPTBX15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Jun 30 20:33:23 CEST 2020
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