TBX15 (T-box transcription factor 15)

2014-08-01  

Identity

HGNC
TBX15
LOCATION
1p12
LOCUSID
6913
ALIAS
TBX14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6913
MIM: 604127
HGNC: 11594
Ensembl: ENSG00000092607

Variants:

dbSNP: 6913
ClinVar: 6913
TCGA: ENSG00000092607
COSMIC: TBX15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092607ENST00000207157Q96SF7
ENSG00000092607ENST00000369429Q96SF7
ENSG00000092607ENST00000449873Q5JT55

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
209356292010Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.396
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
280079802017Archaic Adaptive Introgression in TBX15/WARS2.22
190682782008TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.18
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
261057582015A genome-wide association study identifies multiple loci for variation in human ear morphology.12
288478842017Tbx15 Defines a Glycolytic Subpopulation and White Adipocyte Heterogeneity.12
209625792011Combination of promoter hypomethylation and PDX1 overexpression leads to TBX15 decrease in vascular IUGR placentas.11
236702212014Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio.9
262160262015Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells.5

Citation

Dessen P

TBX15 (T-box transcription factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54693/tbx15