TBX21 (T-box transcription factor 21)

2007-02-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
T-PET,T-bet,TBET,TBLYM

Other Information

Locus ID:

NCBI: 30009
MIM: 604895
HGNC: 11599
Ensembl: ENSG00000073861

Variants:

dbSNP: 30009
ClinVar: 30009
TCGA: ENSG00000073861
COSMIC: TBX21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073861ENST00000177694Q9UL17

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalClinicalAnnotationassociatedPD
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
162730992005Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin.502
222614382012The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.244
172373802007T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity.107
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
250326862014T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.99
198050382009The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.97
212893102011Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.88
185044232008Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.73
198186552009CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus.67
207138802010T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.60

Citation

Dessen P

TBX21 (T-box transcription factor 21)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46077/tbx21